Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos.

Foster, James D.; McKelvey, W.A.C.; Fraser, H.; Chong, Angela; Ross, Arlene; Parnham, David; Goldmann, Wilfred; Hunter, Nora

doi:10.1099/0022-1317-80-2-517

Cited by 30 publications

(28 citation statements)

References 16 publications

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“…Results obtained from scrapie in sheep (Foster et al, 1992(Foster et al, , 1996Foote et al, 1993) or BSE in goats (Foster et al, 1999) did not lead to any striking evidence on this possible pathway of transmission of the TSE agent in small ruminants.…”

Section: Introductionmentioning

confidence: 92%

PrPSc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission

Andréoletti

Lacroux

Chabert

et al. 2002

Journal of General Virology

144

118

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Section: Introductionmentioning

confidence: 92%

PrPSc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission

Andréoletti

Lacroux

Chabert

et al. 2002

Journal of General Virology

144

118

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“…21 In contrast to bovine spongiform encephalopathy (BSE), 35 there is no evidence that scrapie is harmful to humans. However, it has been shown repeatedly that BSE is transmissible to both sheep and goats 15,16 under experimental conditions. Recently Norwegian scientists reported clinical scrapie cases in sheep with unusual diagnostic features.…”

Section: Introductionmentioning

confidence: 99%

Atypical Scrapie in a Swiss Goat and Implications for Transmissible Spongiform Encephalopathy Surveillance

et al. 2007

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Abstract. Different types of transmissible spongiform encephalopathies (TSEs) affect sheep and goats. In addition to the classical form of scrapie, both species are susceptible to experimental infections with the bovine spongiform encephalopathy (BSE) agent, and in recent years atypical scrapie cases have been reported in sheep from different European countries. Atypical scrapie in sheep is characterized by distinct histopathologic lesions and molecular characteristics of the abnormal scrapie prion protein (PrP sc ). Characteristics of atypical scrapie have not yet been described in detail in goats. A goat presenting features of atypical scrapie was identified in Switzerland. Although there was no difference between the molecular characteristics of PrP sc in this animal and those of atypical scrapie in sheep, differences in the distribution of histopathologic lesions and PrP sc deposition were observed. In particular the cerebellar cortex, a major site of PrP sc deposition in atypical scrapie in sheep, was found to be virtually unaffected in this goat. In contrast, severe lesions and PrP sc deposition were detected in more rostral brain structures, such as thalamus and midbrain. Two TSE screening tests and PrP sc immunohistochemistry were either negative or barely positive when applied to cerebellum and obex tissues, the target samples for TSE surveillance in sheep and goats. These findings suggest that such cases may have been missed in the past and could be overlooked in the future if sampling and testing procedures are not adapted. The epidemiological and veterinary public health implications of these atypical cases, however, are not yet known.

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“…Several sources were used to control for TSE strain, host species, and tissue condition (i.e., frozen vs. fixed and wax-embedded) to ensure unequivocal interpretation of the results (Table). Paraffin wax–embedded material from 2 field cases that were contemporary with the suspected case but gave a scrapie profile on D-IHC ( 16 , 17 ) and an experimental caprine BSE case (supplied by Nora Hunter, Roslin Institute, Edinburgh, UK) were used to control for strain variation in material that had been handled and stored in the same way and for a similar time as material from the suspected case ( 21 ). …”

Section: Methodsmentioning

confidence: 99%

Isolation of Prion with BSE Properties from Farmed Goat

Spiropoulos¹,

Lockey²,

Sallis³

et al. 2011

Emerg. Infect. Dis.

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Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos.

Cited by 30 publications

References 16 publications

PrPSc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission

PrPSc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission

Atypical Scrapie in a Swiss Goat and Implications for Transmissible Spongiform Encephalopathy Surveillance

Isolation of Prion with BSE Properties from Farmed Goat

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