Experimental Vertebroplasty Using Osteoconductive Granular Material

Cunin, G.; Boissonnet, Hervé; Petite, Hervé; Blanchat, Cindy; Guillemin, G

doi:10.1097/00007632-200005010-00006

Cited by 86 publications

(34 citation statements)

References 10 publications

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“…Absorption of calcium carbonate can be visualized by radiographs and ex vivo by histomorphometric [22]. In contrast, CPC absorption has been described only by histomorphometric measurements but not by radiological examinations because of the slower absorption rate compared with CaCO 3 [9,10,22].…”

Section: Discussionmentioning

confidence: 99%

CT volumetry of intravertebral cement after kyphoplasty. Comparison of polymethylmethacrylate and calcium phosphate in a 12-month follow-up

et al. 2005

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This study was intended to measure the volume of intravertebral cement after balloon kyphoplasty with high resolution computed tomography (CT) and dedicated software. Volume changes of biocompatible calcium phosphate cement (CPC) were detected during a follow-up of 12 months. Measurements were compared with a control group of patients treated with polymethylmethacrylate (PMMA). Twenty-three vertebrae (14 CPC, 9 PMMA) of 12 patients were examined with CT using an identical imaging protocol. Dedicated software was used to quantify intravertebral cement volume in subvoxel resolution by analyzing each cement implant with a density-weighted algorithm. The mean volume reduction of CPC was 0.08 ml after 12 months, which corresponds to an absorption rate of 2 vol%. However, the difference did not reach significance level (P>0.05). The mean error estimate was 0.005 ml, indicating excellent precision of the method. CT volumetry appears a precise tool for measurement of intravertebral cement volume. CT volumetry offers the possibility of in vivo measurement of CPC resorption.

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Section: Discussionmentioning

confidence: 99%

CT volumetry of intravertebral cement after kyphoplasty. Comparison of polymethylmethacrylate and calcium phosphate in a 12-month follow-up

et al. 2005

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“…The accelerated cell growth might have resulted from the interaction of the hPDCs with components of the fibrin sealant or from differences in substrate stiffness. The major components of fibrin, fibrinogen and thrombin, have both been found to stimulate proliferation of fibroblasts and osteoblasts when added to the culture medium or when bound to the cell culture substrate (Dawes et al, 1993;Gray et al, 1993;Gorodetsky et al, 1998;Frost et al, 1999). Besides fibrinogen and thrombin, fibrin sealants can also contain active growth factors including TGF-1 and bFGF (Cox et al, 2004).…”

Section: J Demol Et Al Fibrin For Osteogenic Differentiation Of Hpdcs?mentioning

confidence: 99%

“…However, not all studies obtained the same result. Some studies attributed excellent osteogenic and osteoinductive properties to fibrin (Kania et al, 1998;Tholpady et al, 1999;Isogai et al, 2000;Perka et al, 2000;Abiraman et al, 2002;Kalia et al, 2009), while others reported nonsignificant positive and negative results (Jarzem et al, 1996;Brittberg et al, 1997;Carmagnola et al, 2000;Cunin et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…For example, Abiraman et al and Kania et al reported that the addition of fibrin to ceramic biomaterials promoted new bone formation as compared to the ceramics alone (Kania et al, 1998;Abiraman et al, 2002). Conversely, Carmagnola et al and Cunin et al showed that the presence of fibrin impaired bone healing (Carmagnola et al, 2000;Cunin et al, 2000). Because of the various outcomes of in vivo studies, it still remains unclear whether fibrin's role in bone regeneration is limited to the delivery of progenitor cells to the defect site or whether fibrin has osteoconductive or even osteoinductive properties that enhance new bone formation.…”

Section: Introductionmentioning

confidence: 99%

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Does tranexamic acid stabilised fibrin support the osteogenic differentiation of human periosteum derived cells?

Demol

Eyckmans²,

Sj³

et al. 2011

eCM

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Fibrin sealants have long been used as carrier for osteogenic cells in bone regeneration. However, it has not been demonstrated whether fibrin's role is limited to delivering cells to the bone defect or whether fibrin enhances osteogenesis. This study investigated fibrin's influence on the behaviour of human periosteum-derived cells (hPDCs) when cultured in vitro under osteogenic conditions in twodimensional (fibrin substrate) and three-dimensional (fibrin carrier) environments. Tranexamic acid (TEA) was used to reduce fibrin degradation after investigating its effect on hPDCs in monolayer culture on plastic. TEA did not affect proliferation nor calcium deposition of hPDCs under these conditions. Expression profiles of specific osteogenic markers were also maintained within the presence of TEA, apart from reduced alkaline phosphatase (ALP) expression (day 14). Compared to plastic, proliferation was upregulated on 2D fibrin substrates with a 220% higher DNA content by day 21. Gene expression was also altered, with significantly (p<0.05) decreased Runx2 (day 7) and ALP (day 14) expression and increased collagen I expression (day 14 and 21). In contrast to plastic, mineralisation was absent on fibrin substrates. Inside fibrin carriers, hPDCs were uniformly distributed. Moderate cell growth and reduced osteogenic marker expression was observed inside fibrin carriers. After 2 weeks, increased cell death was present in the carrier's centre. In conclusion, fibrin negatively influences osteogenic differentiation, compared to culture plastic, but enhanced proliferation (at least in 2D cultures) for hPDCs cultured in osteogenic conditions. TEA maintained the integrity of fibrin-based constructs, with minor effects on the osteogenic differentiation of hPDCs.

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“…Adjunction of a binding agent such as fibrin glue may stabilize the granules in the implantation site and produce a composite that can be moulded into the defect without empty spaces. 8,9 Many processing routes have been used for the fabrication of porous hydroxyapatite granules, such as hydrothermal conversion of natural corals 10 and crushing of sintered blocks, granulation by vibration and rolling, 11 dripping procedure, 12 casting in plaster mould, 13 emulsion methods 14,15 and the spraydrying process. 16 However, these processes do not yield granules with optimal properties for medical applications.…”

Section: Introductionmentioning

confidence: 99%