Experimental Vascular Grafts. I. The Effects of Dicetyl Phosphate on Venous Autografts Implanted in the Thoracic Aorta of Growing Pigs

Ea, Kanar; Ej, Schmitz; Lr, Sauvage; Lm, Nyhus; Hg, Moore; Ka, Merendino; Hn, Harkins

doi:10.1097/00000658-195307000-00009

Cited by 2 publications

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“…One other pig in this group of five animals showed aneurysmal dilatation of its graft but accurate measurements could not be obtained because the graft was damaged during its removal. 1. Three of the grafts obtained in this rather early postoperative period were isodimensional at the time of death.…”

Section: Resultsmentioning

confidence: 98%

Experimental Vascular Grafts

et al. 1954

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This report represents a further study of the problems proposed in a previous communication, by Kanar et al. (1), who compared five fresh autogenous vein grafts implanted into the thoracic aortas of growing pigs with five similar grafts surrounded by crystalline dicetyl phosphate. Their conclusions were that: 1. Venous autografts implanted in the thoracic aorta of weanling pigs dilate and may rupture, 2. Dicetyl phosphate applied about such a graft may restrict subsequent enlargement or dilatation as well as linear growth both of the graft and adjacent aorta, and possibly result in decreased growth of the entire animal. Questions to be answered were: 1. Would the use of dicetyl phosphate result in a greater incidence of late graft complications such as stenosis and calcification? and 2. Would use of such a fibroblastic substance effectively prevent dilatation of fresh venous autografts?Historically, Poppe and De Oliviera (2) in 1946 treated aneurysms of major vessels by wrapping them with active cellophane. Two years later Yeager and Cowley (3) identified the active ingredient as dicetyl phosphate. The literature contains reports of aneurysms successfully treated (4, 5) by dicetyl phosphate applications. It is essential that this substance be further evaluated because it may prove a valuable and less dangerous treatment for aneurysms associated with severe vascular disease.

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Section: Resultsmentioning

confidence: 98%