Experimental uterus transplantation

Johannesson, Liza; Enskog, Anders

doi:10.1016/j.bpobgyn.2014.07.018

Cited by 14 publications

(9 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on these, it cannot be denied that UTx is still under development as a reproductive medicine and organ transplant procedure. Future efforts will be required to treat patients with UFI successfully . Additonally, in Japan, a collaborative system that is not limited by facilities and specialties should strive to build an “all‐Japan” team.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Uterus transplantation: Toward clinical application in Japan

Suganuma

Hayashi

Kisu³

et al. 2017

Reprod Medicine & Biology

View full text Add to dashboard Cite

BackgroundIn recent years, uterus transplantation (UTx) has been applied as the treatment for patients with uterine factor infertility worldwide. Thus, the clinical application of UTx in Japan should be considered through both the history of UTx technology development in the world and future prospects.MethodsRecent information on UTx was collected via a literature survey and the Internet.ResultsBasic research using various animals has been done mainly since 2000. In 2014, the world's first UTx baby was born in Sweden. In total, 24 UTx procedures have been performed at 10 institutes in nine countries and five births were obtained (as of May, 2017). In Japan, the “Project Team for Uterus Transplantation” initiated UTx experiments in 2008 and the “Japan Society for Uterus Transplantation” was organized in March, 2014. In the rest of the world, the “International Society for Uterus Transplantation” was established in January, 2016.ConclusionUterus transplantation is still under development as a reproductive medicine tool and organ transplant procedure. A collaborative system that is not limited by facilities and specialties should strive to build an “all‐Japan” team.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Future efforts will be required to treat patients with UFI successfully. 101,[119][120][121][122][123][124][125][126] Additonally, in Japan, a collaborative system that is not limited by facilities and specialties should strive to build an "all-Japan" team.…”

Section: Discussionmentioning

confidence: 99%

Uterus transplantation: Toward clinical application in Japan

Suganuma

Hayashi

Kisu³

et al. 2017

Reprod Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…Organ transplantation is no longer reserved for those with a life-threatening disease and neither is organ transplantation together with concurrent immunosuppression a contraindication for pregnancy [8]. The science and research that led to the Swedish team's success evolved over years from work done in basic primate labs to gynecology operating rooms.…”

Section: Discussionmentioning

confidence: 99%

Human Uterus Transplantation: Have We Opened a Pandora’s Box?

Allahbadia

2015

J Obstet Gynecol India

View full text Add to dashboard Cite

“…No live births have been reported to date from this attempt. 25 After the feasibility of human uterus transplantation was demonstrated in these studies, researchers attempted to move forward with clinical trials. Brännström et al conducted the first prospective clinical study on uterus transplantation in 2012-2013, consisting of a cohort of nine women at Sahlgrenska University Hospital in Gothenburg, Sweden.…”

Section: Review Of the Scientific Researchmentioning

confidence: 99%

“…Furthermore, there remains a risk of premature delivery and low birthweight, though it is unclear whether this is due to the mother's underlying medical comorbidities. 1,3,25,35,36 Second, in the case of acute vascular thrombosis, it is unclear what the impact of hypoxia would be on the developing fetus. Due to these concerns, it is imperative that patients account for risks to the future child in their decision-making processes and that physicians recognize their double responsibility -both to the intended mother and to the future child.…”

mentioning

confidence: 99%

Ethical considerations in uterus transplantation

Woessner¹,

Blake²,

Arora³

2015

View full text Add to dashboard Cite

Uterus transplantation offers a novel treatment option for women with uterine factor infertility. While currently in the early clinical research phase, uterus transplantation will likely provide an alternative to adoption or gestational surrogacy, which is not permitted in some parts of the world. It uniquely allows for women with uterine factor infertility to experience the gestational component of motherhood and also to potentially share a genetic link with the offspring. Clinical research on uterus transplantation has been in process since the 1960s, and the first human live birth following transplant was reported in 2014. However, given the rapid clinical advancement, it is important to review the medical safety of the procedure and ethical dilemmas for the donor, recipient, and resulting child as well as the regulatory landscape that will ultimately guide clinical adoption. Given that uterus transplantation brings together the challenges of both assisted reproductive technology as well as organ transplantation as the world's first ephemeral transplant, it is important to discuss the ethical, legal, and social implications prior to moving from research to widespread clinical practice. Keywords: ethics, regulation, infertility Ethical considerations in uterus transplantationOrgan transplantation has been performed since the early 20th century for a variety of reasons, including restoring function, saving life, and extending lives. Organ transplantation raises its own ethical considerations, including the use of cadaveric or living donors, allocation of scarce resources, use of medical and other criteria to determine eligibility, and informed consent.1-3 Improving the quality of a patient's life, rather than saving life itself, is a more recent goal and achievement of organ transplant (eg, hand, corneal, and face transplants) that presents further ethical considerations.1,3 For example, it is unclear how much risk is justified in the face of interventions aimed at improving quality of life rather than saving life. Uterus transplantation raises these same issues along with novel ones. For example, it is the first organ transplant with the goal being reproduction. Also, uterus transplantation is the first ephemeral organ transplant, or a transplant designed specifically for a short term, rather than the anticipated long-term nature of a transplanted liver or kidney, for example.As a transplant with reproduction as its goal, it necessarily raises ethical questions about technological aid of reproduction, including the rights of any reproductive donors, the interests of the child, commodification of women's bodies, the interests and goals of the mother, and the role of the state in regulating women's bodies and reproduction.

show abstract

Experimental uterus transplantation

Cited by 14 publications

References 77 publications

Uterus transplantation: Toward clinical application in Japan

Uterus transplantation: Toward clinical application in Japan

Human Uterus Transplantation: Have We Opened a Pandora’s Box?

Ethical considerations in uterus transplantation

Contact Info

Product

Resources

About