Experimental uterotubovarian homotransplantation in the dog

Wingate, M. B.; Karasewich, Eugene G.; Wingate, La’Marcus T.; Lauchian, S.; Ray, M.

doi:10.1016/0002-9378(70)90512-0

Cited by 18 publications

(11 citation statements)

References 7 publications

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“…For example, pigs reject homo grafts of skin or kidney in a conventional manner while rejection of the liver is a slow and sometimes remarkably mild process, being accepted for up to nine months in the absence of any immunosuppressive agent [2]. Al though other tissues and organs have been studied extensively, relatively little information is available regarding the fate of the homotransplanted uterus [7][8][9][10].…”

mentioning

confidence: 99%

Uterine Transplantation in Dogs

Scott

Anderson

Kling

et al. 1970

Gynecol Obstet Invest

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An experimental surgical procedure of uterine transplantation using the omentum as a vascular supply was performed in 20 dogs. Eight of the 10 uterine autografts were considered viable. Five of the 10 dogs with homografts were treated with immunosuppressive drugs, but no significant differences in the rejection reaction between the 2 groups were noted. The described clinical behavior, laboratory studies, and gross and microscopic findings supply more information about the rejection characteristics of this organ.

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mentioning

confidence: 99%

Uterine Transplantation in Dogs

Scott

Anderson

Kling

et al. 1970

Gynecol Obstet Invest

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“…Four experimental groups (all with uteri from BN rats) were included: [1] transplanted LW rats treated with tacrolimus (UTx-TAC; n ¼ 7); [2] transplanted LW rats not receiving tacrolimus (UTx-nonTAC; n ¼ 5); [3] BN rats treated with tacrolimus (Sham-TAC; n ¼ 6); and [4] sham-operated BN rats without tacrolimus treatment (Sham-surgery; n ¼ 5). Postoperative care was identical in all groups and consisted of buprenorphine (0.005 mg/kg once a day; Temgesic, Schering-Plough), carprofen (5.0 mg/kg once a day; Rimadyl, Pfizer), low molecular weight heparin (100 IU/kg once a day; Fragmin; Pfizer), and trim-sulfa (100 þ 20 mg/kg once a day; Bimotrim, CEVA Vetpharma).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…The immunosuppressants (IS) used at that time proved not to be able to prevent rejection of these allogeneic uterotubal grafts (3,4). The introduction of several new immunosuppressive pharmacologic agents, and in particular the calcineurin inhibitors cyclosporine and tacrolimus, has made it possible to transplant a variety of organs including highly immunogenic tissues such as the hand (5) and face (6).…”

mentioning

confidence: 99%

Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus

Akhi

Díaz-García

El-Akouri

et al. 2013

Fertility and Sterility

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“…The immunosuppressive agents available during the 1960s to 1970s, azathioprine and cortisone, may have had some anti‐rejection effects, as indicated by variable degrees of rejection of the utero‐tubal‐ovarian transplants at evaluation up to seven weeks after transplantation, 46 but that study did not include a proper control group of non‐treated animals. In another study, with an untreated group for comparison, the untreated allogenic transplanted uteri showed hemorrhage, patchy necrosis and intravascular thrombosis in the uterine arteries after just one week 44 . The dogs, treated with azathioprine and cortisone, were examined after four weeks.…”

Section: Uterus Transplantationmentioning

confidence: 99%

Transplantation of female genital organs

Brännström

Díaz-García

2011

J of Obstet and Gynaecol

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Transplantation of gynecological organs is a medical field where considerable advancements have been made in research during the last 25 years and with some procedures already introduced as clinical treatments. These types of transplantations aim at curing permanent infertility. Uterus transplantation has been proven to be a feasible procedure in different experimentation animal models with proof of concept concerning surgery, control of rejection and fertility. There has already been one human transplantation attempt, which, however, was unsuccessful. Based on the progress in this area, we predict that the first successful uterus transplantation attempt will come within 2-3 years. Orthotopic ovarian cortex transplantation has overcome the status of an experimental procedure since more than 20 pregnancies have been reported. Its main field of application is fertility preservation in oncologic patients undergoing high gonadotoxic risk therapies. The role of heterotopic ovarian cortex transplantation still remains at the research level, although co-transplantation with an orthotopic cortex might facilitate a more accurate endocrine environment. The major drawback of ovarian cortex transplantation remains the long ischemic interval between re-implantation and the establishment of neovascularization. Whole ovary cryopreservation followed by transplantation through vascular anastomosis may emerge as an important procedure in this field, because the warm ischemic time would be reduced from several days to less than 1 h, which will most likely improve follicle survival. In summary, transplantation surgery is also entering the field of gynecology and in the future several types of transplantations of organs/tissues of the female reproductive tract may become established clinical procedures.

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Experimental uterotubovarian homotransplantation in the dog

Cited by 18 publications

References 7 publications

Uterine Transplantation in Dogs

Uterine Transplantation in Dogs

Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus

Transplantation of female genital organs

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