Experimental Treatment of the Acute Cardiovascular Toxicity of Caffeine

Abstract

Ventricular ectopia leading to fibrillation accounts for the lethal outcome of caffeine poisoning in anesthetized rats and can be antagonized by treatment with propranolol or verapamil.

Dietary factors and incident atrial fibrillation: the Framingham Heart Study

“…Caffeine is widely present in many dietary sources and may mediate AF by resulting in neurohormonal stimulation and sympathetic activation (28,29). The clinical effect of intakes of caffeine from coffee, tea, and caffeinated soda on AF remains inconclusive.…”

Hypotensive effect of aqueous extract of Averrhoa carambola L. (Oxalidaceae) in rats: An in vivo and in vitro approach

“…All drugs were dissolved in pyrogen-free isotonic saline. The doses used in the present study were selected based on previous studies (Filep et al, 1996;Pechánová et al, 1999;Strubelt and Diederich, 1999;Giusti-Paiva et al, 2004;Medeiros et al, 2006;Waki et al, 2006;Dhalla et al, 2006).…”

Effects of Caffeine and Coffee Consumption on Cardiovascular Disease and Risk Factors

“…The sympathomimetic effects of circulating catecholamines cause the cardiac manifestation of caffeine overdose [64]. Caffeine toxicity produces supraventricular tachycardia, atrial fibrillation and ventricular fibrillation [65,66].…”