Experimental Transmission of Simian Acquired Immunodeficiency Syndrome (Saids) and Kaposi-Like Skin Lesions

Neoplasms and Proliferative Disorders in Nonhuman Primates

“…The lesions were similar to "subcutaneous fibromatosis" in a recent report [115] and may be a variant of retroperitoneal fibromatosis. Similar experimentally produced lesions have also been called "Kaposi's-like skin lesions" [73].…”

Simian AIDS—Evidence for a retroviral etiology

“…Before an infectious virus was identified, its presence was inferred by the successful transmission of SAIDS to normal monkeys, done independently at the New England and California Centers, the latter in collaboration with Dr John Sever's laboratory at NIH (Letvin et aI., 1983b;London et al, 1983;Gravell et al, 1984a). The initial seroepidemiologic and virologic studies tended to rule out as primary etiologic agents a number of indigenous rhesus viruses, including CMV, EBV, Herpes simiae, adenovirus, parvovirus and HTLV.…”

“…This simian model of AIDS-Called 'SAIDS'-is quite similar to human AIDS in its overall clinical manifestations, pathology and immunology. SAIDS was readily transmissible to normal rhesus monkeys by cage contact and experimental inoculation of tissue extracts, whole blood, serum or filtered plasma (Letvin et al, 1983b;London et al, 1983;Gravell et al, 1984a). Very recently, a type D retrovirus, related to but distinct from the Mason-Pfizer monkey virus (MPMV), was found associated with SAIDS at these two Primate Centers (Daniel et al, 1984;Marx et al, 1984).…”

A brief history of the discovery of natural simian immunodeficiency virus (SIV) infections in captive sooty Mangabey monkeys

“…Some studies showed that SAIDS could be transmitted using cell-free inoculum from macaque lymphoma, although lymphoma was not transmitted (46). SAIDS could be transmitted in macaques using supernatants from homogenized tissues, whole blood and plasma from type D retrovirus-positive macaques (47,48). Other laboratories isolated type D retrovirus from macaques (47)(48)(49)(50) and showed that this virus could produce experimental SAIDS (48,51,52).…”