Experimental system for measuring the full scattering profile of circular phantoms

Feder, Idit; Duadi, Hamootal; Fixler, Dror

doi:10.1364/boe.6.002877

Cited by 44 publications

(27 citation statements)

References 17 publications

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“…It is assumed that the absorption and scattering characteristics of tissue change during the progression of disease [11]. The main phenomenon that we present here is the isobaric point that we reveal by the FSP [12,13]. This point is a common point for different profiles of cylindrical tissues which are characterized by different optical properties.…”

Section: Introductionmentioning

confidence: 73%

Experimental results of full scattering profile from finger tissue-like phantom

Feder

Wróbel

Duadi

et al. 2016

Biomed. Opt. Express

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Human tissue is one of the most complex optical media since it is turbid and nonhomogeneous. We suggest a new optical method for sensing physiological tissue state, based on the collection of the ejected light at all exit angles, to receive the full scattering profile. We built a unique set-up for noninvasive encircled measurement. We use a laser, a photodetector and finger tissues-mimicking phantoms presenting different optical properties. Our method reveals an isobaric point, which is independent of the optical properties. We compared the new finger tissues-like phantoms to others samples and found the linear dependence between the isobaric point's angle and the exact tissue geometry. These findings can be useful for biomedical applications such as non-invasive and simple diagnostic of the fingertip joint, ear lobe and pinched tissues.

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Section: Introductionmentioning

confidence: 73%

Experimental results of full scattering profile from finger tissue-like phantom

Feder

Wróbel

Duadi

et al. 2016

Biomed. Opt. Express

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“…Detecting clinical-level changes in the parameters of bodily fluids, such as intracranial cerebrospinal fluid pressure [1], blood glucose levels [2,3], microvasculature blood flow rates [4] as well as the parameters of the blood itself [5][6][7] are of great importance and are extensively studied. Optical phantoms are used mainly for calibration and development of these optical measurement and imaging systems [8,9]. They serve as reference standards for comparison of devices and techniques as well as for studying light transport in complex, often multi-layered tissues or organs with internal vasculature [10,11].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering

Wróbel

Попов

Bykov

et al. 2016

Biomed. Opt. Express

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We present an alternative to the conventional approach, phantoms without scattering nanoparticles, where scattering is achieved by the material itself: spherical cavities trapped in a silicone matrix. We describe the properties and fabrication of novel optical phantoms based on a silicone elastomer polydimethylsiloxane (PDMS) and glycerol mixture. Optical properties (absorption coefficient µa , reduced scattering coefficient µs' , and anisotropy factor g) of the fabricated phantoms were retrieved from spectrophotometric measurements (in the 400-1100 nm wavelength range) using the inverse adding-doubling method. The internal structure of the phantoms was studied under a scanning electron microscope, and the chemical composition was assessed by Raman spectroscopy. Composition of the phantom material is reported along with the full characterization of the produced phantoms and ways to control their parameters.

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“…Therefore, the range above 145° that is not included in the experiment measurements, does not interfere with our conclusions. In addition in our previous work we measured the isobaric point experimentally for phantoms with different optical parameters. Whereas the percentage of the shielding effect's influence on the light intensity is reduced in the higher angles, as we have shown in Figure , we assumed that the isobaric point can be measured also in this research if we succeed to measure the full scattering profile in the higher angles, and in accordance with the simulation results.…”

Section: Discussionmentioning

confidence: 99%

The influence of the blood vessel diameter on the full scattering profile from cylindrical tissues: experimental evidence for the shielding effect

et al. 2015

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Optical methods for detecting physiological state based on light-tissue interaction are noninvasive, inexpensive, simplistic, and thus very useful. The blood vessels in human tissue are the main cause of light absorbing and scattering. Therefore, the effect of blood vessels on light-tissue interactions is essential for optically detecting physiological tissue state, such as oxygen saturation, blood perfusion and blood pressure. We have previously suggested a new theoretical and experimental method for measuring the full scattering profile, which is the angular distribution of light intensity, of cylindrical tissues. In this work we will present experimental measurements of the full scattering profile of heterogenic cylindrical phantoms that include blood vessels. We show, for the first time that the vessel diameter influences the full scattering profile, and found higher reflection intensity for larger vessel diameters accordance to the shielding effect. For an increase of 60% in the vessel diameter the light intensity in the full scattering profile above 90° is between 9% to 40% higher, depending on the angle. By these results we claim that during respiration, when the blood-vessel diameter changes, it is essential to consider the blood-vessel diameter distribution in order to determine the optical path in tissues. A CT scan of the measured silicon-based phantoms. The phantoms contain the same blood volume in different blood-vessel diameters.

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Experimental system for measuring the full scattering profile of circular phantoms

Cited by 44 publications

References 17 publications

Experimental results of full scattering profile from finger tissue-like phantom

Experimental results of full scattering profile from finger tissue-like phantom

Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering

The influence of the blood vessel diameter on the full scattering profile from cylindrical tissues: experimental evidence for the shielding effect

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