Experimental Surgery of the Skeletal System

Arnoczky, Steven P.; Wilson, James W.

doi:10.1016/b978-0-12-278008-0.50007-2

Research Surgery and Care of the Research Animal 1986

DOI: 10.1016/b978-0-12-278008-0.50007-2

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Experimental Surgery of the Skeletal System

Steven P. Arnoczky

James W. Wilson

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2014

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“…Primary bone healing occurs without callus formation and the secondary bone healing occurs with a callus precursor stage 1,2 . The major diaphyseal fracture models are from animals like mouse, rat, rabbit 3,4 . Although the bones of some animals (e.g.…”

mentioning

confidence: 99%

Effects of Ofloxacin on Experimental Fracture Healing in Wistar Rats

Shetty¹,

Udyavar

Rao

et al. 2014

J. Drug Delivery Ther.

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Bone heals by bone. Fractured bone can be replaced to its original form without formation of scar. The process of fracture healing can occur in two ways. Primary bone healing occurs without callus formation and the secondary bone healing occurs with a callus precursor stage 1,2 . The major diaphyseal fracture models are from animals like mouse, rat, rabbit 3,4 . Although the bones of some animals (e.g. rat and sheep) differ physiologically from human bone (i.e. they do not undergo normal haversian remodellation), they have been widely used in orthopaedic research 4,5,6 . Ofloxacin is a synthetic chemotherapeutic antibiotic of the second generation fluoroquinolone. The fluoroquinolones interfere with DNA replication by inhibiting an enzyme complex called DNA gyrase. Recent studies have demonstrated a correlation between mammalian cell cytotoxicity of the quinolones and the induction of micronuclei 7 . As such some fluoroquinolones may cause injury to the chromosome of eukaryotic cells. It is not recommended for usage in children because of serious reversible and irreversible musculoskeletal adverse effects.

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mentioning

confidence: 99%

Effects of Ofloxacin on Experimental Fracture Healing in Wistar Rats

Shetty¹,

Udyavar

Rao

et al. 2014

J. Drug Delivery Ther.

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Experimental Surgery of the Skeletal System

Cited by 1 publication

References 102 publications

Effects of Ofloxacin on Experimental Fracture Healing in Wistar Rats

Effects of Ofloxacin on Experimental Fracture Healing in Wistar Rats

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