Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress

Самотруева, М. А.; Ясенявская, А. Л.; Murtalieva, V Kh; Bashkina, Olga; Myasoedov, N. F.; Andreeva, L. A.; Karaulov, Alexander

doi:10.1007/s10517-019-04434-y

Cited by 12 publications

(8 citation statements)

References 2 publications

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“…The anxiolytic, antistressor, nootropic and other properties of this drug have been confirmed in various studies [6,7]. Despite accumulated data from the clinical studies on the spectrum of their pharmacological activities, the properties of new neuropeptide compounds have been actively researched.…”

Section: Yasen_9@mailru Introductionmentioning

confidence: 89%

Effects of Glyprolines on the Behavior of Ratsin the Porsolttest and Experimentallyinduced Socials

Самотруева¹,

Ясенявская²,

Цибизова³

et al. 2020

AREM

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In this work we studied the effect of glyprolines on the behavior of rats under conditions of experimental social stress. White male rats 6-8 months of age were used in the experiment. Throughout the experiment all animals were kept in standard-barrier conditions. The effect of glyprolines on the behavior of white male rats was studied on the model of social stress, implying that the animals are kept in conditions of a constant sensory contact. Glyprolines (Selank, Pro-Gly-Pro, Pro-Gly-Pro-Leu) were injected to the animals Intraperitoneally at a dose of 100 μg/kg/day within 20 days. Porsolt test was employed to carry out behavioral analysis in the animals. The outcomes revealed that regardless of the type of behavior (aggressive and submissive) in all the animals depression and anxiety disorders were developed, whereas Selank, Pro-Gly-Pro, Pro-Gly-Pro-Leu facilitated their alleviation. Thus, our experiment has demonstrated a psychomodulatory effect of the glyprolines.

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Section: Yasen_9@mailru Introductionmentioning

confidence: 89%

Effects of Glyprolines on the Behavior of Ratsin the Porsolttest and Experimentallyinduced Socials

Самотруева¹,

Ясенявская²,

Цибизова³

et al. 2020

AREM

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“…Previously, the presence of antioxidant action and the ability of melanocortins to influence the level of pro-and anti-inflammatory cytokines have been proven. It has been established that Semax (ACTH(4-7)-Pro-Gly-Pro) and ACTH(6-9)-Pro-Gly-Pro under conditions of social stress cause an inhibition of free radical oxidation processes and reduce the concentration of pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α [9,10].…”

Section: R E S U L T Smentioning

confidence: 99%

Effect of Melanocortins and Experimental Social Stress on the Level of Caspase-3 and Caspase-8

Ясенявская¹,

Цибизова²,

Andreeva³

et al. 2021

ArveMED

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At present the study of stress-generating effects and key mechanisms of regulation of apoptosis remain in the focus of attention of researchers. Stress causes dysfunctions of many body systems which lead to disruption of homeostasis and molecular cell mechanisms of programmed cell death. In this context, the problem of pharmacological regulation and correction of these disorders poses an urgent problem. Neuropeptide compounds such as melanocortins are interesting in this direction as regulators and correctors. Under conditions of experimental social stress activation of apoptotic processes was established due to an increase in the level of caspase-3 and caspase-8. The studied neuropeptides Semax (ACTH (4-7)-Pro-Gly-Pro) and ACTH (6-9)-Pro-Gly-Pro exhibit antiapoptotic effects under conditions of induced social stress in rats. This action of neuropeptides is manifested by a decrease in the activity of the initiating and effector caspases in the blood serum of experimental animals.

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“…There is a promising trend to use for correction of pathological conditions of the nervous system drugs from the group of analogs of neuropeptides which are similar to natural endogenous regulators of the body functions. [4,5,6,8]. Melanocortins are synthesized at the Kurchatov Institute of Molecular Genetics (Moscow, Russia).…”

Section: Introductionmentioning

confidence: 99%

Effects of Melanocortinson the Behavior of Ratsin Thetest Ofelevated Cruciform Maze and Experimentally Induced Ofsocials

Ясенявская¹,

Самотруева²,

Цибизова³

et al. 2020

AREM

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— In this study we have investigated the effects of melanocortins (group analogs of neuropeptides) on the psychoemotional state of rats under conditions of experimental social stress. The study was carried out on male rats which were injected intraperitoneally for 20 days with the neuropeptide drugs Semax and ACTH(6-9)-ProGly-Pro at a dose of 100 μg/kg/day starting from the 1st day of stress exposure. The psychoemotional state of the animals was evaluated by means of the behavioral test of elevated cruciform maze. It was found that intraperitoneal administration of neuropeptides (Semax, ACTH(6-9)- Pro-Gly-Pro) helps to reduce high anxiety levels in animals both with aggressive and submissive types of behavior under conditions of experimental social stress via their psychomodulatory effects.

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Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress

Cited by 12 publications

References 2 publications

Effects of Glyprolines on the Behavior of Ratsin the Porsolttest and Experimentallyinduced Socials

Effects of Glyprolines on the Behavior of Ratsin the Porsolttest and Experimentallyinduced Socials

Effect of Melanocortins and Experimental Social Stress on the Level of Caspase-3 and Caspase-8

Effects of Melanocortinson the Behavior of Ratsin Thetest Ofelevated Cruciform Maze and Experimentally Induced Ofsocials

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