This dissertation research emphasizes on achieving high capacity demand of next generation mobile networks (NGMN), i.e. fifth generation (5G), with small cells, i.e. femtocells, deployed in 3-dimensional (3D) indoor coverages by employing such procedures as managing co-channel interference, enforcing a minimum distance, reusing spectrum, and splitting control-plane and user-plane (C-/U-plane) of femtocells. In conventional mobile networks, a common feature is tightly coupled C-/U-plane architecture (CUCA) which is one of the major reasons for most of the problems that small cell network densification faces, e.g. complex interference management. This call for developing a new C-/U-plane split architecture (CUSA) by decoupling C-/U-plane. Further, in cellular mobile networks, most of the data traffic is generated within indoor coverages, mainly in urban environments where an existence of dense high rise multi-floor buildings is a typical scenario. Furthermore, mobile radio propagation in 3D scenario is far more complex than that of 2D scenario. These cause such inevitable issues as small cell network architecture modeling and interference characterization, resource reuse and allocation strategy development, and small cell densification limit characterization to call for their in-depth investigation and the development of new design technique for 3D in-building small cell networks. This dissertation research addresses these aforesaid issues. More specifically, the following objectives are addressed in this dissertation: (i) a review on enabling technologies for proposing a framework of NGMN architectural evolution to achieve the prospective capacity of NGMN; for cell-centric networks, (ii) an adaptive almost blank subframe (ABS) based enhanced intercell interference coordination (eICIC) enabled frequency reuse and scheduling algorithm (FRSA) for an orthogonal resource reuse and allocation (ORRA), (iii) a tractable analytical model for interference characterization and minimum distance enforcement for non-ORRA (NORRA), and (iv) a novel clustering approach along with developing a number of strategies to reuse resources in femtocells within a 3D multi-floor building; for device-centric networks, (v) a novel multi-band enabled small cell and UE architecture for uplink/downlink (UL/DL) and C-/U-plane splitting, (vi) numerous small cell base station (SCBS) architectures for performance comparisons between CUCA and CUSA, and (vii) a centralized 3D radio resource allocation and scheduling approach for CUSA.