Experimental Study on the Viscosity and Adhesive Performance of Exogenous Liquid Fibrin Glue

Abstract

Exogenous fibrin glue (FG) is highly suitable for neurosurgical procedures, because of its viscosity and adhesive properties. Several FGs are commercially available, but only few reports detail their differences. In the present study, we investigated the viscosity and adhesive performance of two types of FG: one is derived from blood donated in Europe and the United States (CSL Behring's Beriplast ® , BP) and the other is derived from blood donated in Japan (the Chemo-Sero-Therapeutic Research Institute's Bolheal ® , BH). The viscosity test that measured fibrinogen viscosity revealed that BP had significantly higher viscosity than BH. Similarly, the dripping test showed that BP traveled a significantly shorter drip distance in the vertical direction than BH, although the transverse diameter of the coagulated FG did not differ statistically significantly. In the tensile strength test, BP showed superior adhesion performance over BH. The histological study of the hematoxylin-eosin-stained specimens in both groups showed favorable adhesion. Although further studies are required on its manufacturing and usage methods, FG shows differences in viscosity and adhesive performance according to the blood from which it is derived. We conclude that it is desirable to select the type and usage method of FG according to the characteristics of the surgical operation in question. Our findings suggest that FG produced from the blood donated in Europe and the United States might be more suitable for use in surgical procedures that demand an especially high degree of viscosity and rapid adhesive performance.

Investigation of the appropriate viscosity of fibrinogen in repairing pleural defects using ventilation and anchoring in an ex vivo pig model

“…The viscosity of Beriplast P ® [CSL Behring, King of Prussia, Pennsylvania, USA] used in the previous study was 42.9 [ 18 ], nearly equivalent to the viscosity adjusted to a higher level for use in this study. The results of this study revealed that fibrinogen with a lower viscosity level exhibited significantly higher rupture pressure, suggesting that the V/A method should employ fibrinogen with a lower viscosity level.…”

Polyester-based photocrosslinkable bioadhesives for wound closure and tissue regeneration support

“…Both macromers present low viscosity, although the values obtained for macLA are lower than those for macCL (about 0.5 and 1.2 Pa.s, respectively). According to studies presented in the literature (including tests on commercial adhesives), the viscosity values obtained are within the desired range for this type of application, considering that the materials must be easy to apply, spread and adapt to the injured area, without compromising the strength of the material and without leading to unwanted migration and adhesion to the surrounding tissues [27][28][29].…”

Asymmetrical Forces Dictate the Distribution and Morphology of Platelets in Blood Clots

“…Platelets move in a fibrin gel, which is a viscoelastic environment. The viscosity was added according to Newton’s law F = − 6 × π × µ × R × V , where µ is the viscosity of the medium ( µ = 1 or 10 mPa·s for the fibrin network) [ 11 , 12 ] and V is the platelet velocity. The elastic component of the fibrin gel was represented by an additional spring between each pair of platelets.…”