Experimental study on the mechanical strain of corneal collagen

Sé, Avetisov; Ia, Bubnova; Ia, Novikov; Antonov, A.A.; Siplivy, V. I.

doi:10.1016/j.jbiomech.2013.04.008

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…Some work [13–15] is available on the imaging and modeling of their microstructure under load and deformation. Studies on the imaging of deformed or deforming real soft tissue microstructure are given in [16–19] and in [20, 21] for eye tissue. Specifically, the biaxial stretch of porcine and bovine heart tissue was imaged using small angle light scattering in [16] and found to produce nonaffine deformation.…”

Section: Introductionmentioning

confidence: 99%

“…In [20] an ultrasound elasticity microscope was used in conjunction with finite element methods to determine corneal strain. Corneal mechanical strain mappings were determined in [21] using polarized light microscopy, with a view toward an in-vivo method. The method produces strain fields in the overall cornea based on luminescence of strained collagen.…”

Section: Introductionmentioning

confidence: 99%

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Imaging of Scleral Collagen Deformation Using Combined Confocal Raman Microspectroscopy and Polarized Light Microscopy Techniques

et al. 2016

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This work presents an optospectroscopic characterization technique for soft tissue microstructure using site-matched confocal Raman microspectroscopy and polarized light microscopy. Using the technique, the microstructure of soft tissue samples is directly observed by polarized light microscopy during loading while spatially correlated spectroscopic information is extracted from the same plane, verifying the orientation and arrangement of the collagen fibers. Results show the response and orientation of the collagen fiber arrangement in its native state as well as during tensile and compressive loadings in a porcine sclera model. An example is also given showing how the data can be used with a finite element program to estimate the strain in individual collagen fibers. The measurements demonstrate features that indicate microstructural reorganization and damage of the sclera’s collagen fiber arrangement under loading. The site-matched confocal Raman microspectroscopic characterization of the tissue provides a qualitative measure to relate the change in fibrillar arrangement with possible chemical damage to the collagen microstructure. Tests and analyses presented here can potentially be used to determine the stress-strain behavior, and fiber reorganization of the collagen microstructure in soft tissue during viscoelastic response.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Imaging of Scleral Collagen Deformation Using Combined Confocal Raman Microspectroscopy and Polarized Light Microscopy Techniques

et al. 2016

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“…Luminescent polariscopy revealed that after radial keratotomy, the main mechanical strain fell on the middle periphery of the cornea, particularly on the bottom of keratotomic incisions. An increase of intracameral pressure (analogue to intraocular pressure) raises the strain on peripheral part of the cornea and off-loads its central part, which can cause hypermetropic shift in refraction [34].…”

Section: Cornea After Refractive Surgerymentioning

confidence: 99%

Biomechanics of Eye Globe and Methods of Its Study

Bubnova¹

2019

Biomechanics

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Knowledge of biomechanical properties of eye globe is necessary both for correct selection of candidates for refractive surgery and right choice of operative intervention parameters. No less important, it is for corneal ectatic disease diagnostics and monitoring. Also it gives inestimable contribution for interpretation of intraocular pressure (IOP) indices especially in cases with irregular eye shape or after past corneal surgical procedures. Moreover, it allows studying injury mechanism by glaucoma process on optic nerve head fibers. Above it, scleral biomechanical properties research is necessary for the investigation of pathophysiologic factors of myopia manifestation and progression. This chapter is devoted to review of existed to date methods of study of eye fibrous tunic biomechanical properties. It describes mathematical, experimental, and clinical models provided evaluation of unsearchable by direct measurement parameters. It also observes effective technics of impact on both sclera and cornea with the aim of correction of its biomechanical condition.

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“…Анизотропные свойства роговицы усиливаются в результате существующего в ней постоянного механического напряжения, направленного по касательной к ее поверхности и связанного с уровнем внутриглазного давления (ВГД). Доказано, что величина оптической анизотропии зависит не только от уровня ВГД, но и от локальных биомеханических свойств и толщины роговицы и может существенно изменяться в объеме [34].…”

Section: физические аспекты светопропускания и светорассеяния роговицейunclassified

Corneal transparency: anatomical basis and evaluation methods

Sé

Narbut

2017

Vestn. oftal'mol.

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Being just a relatively small part of the fibrous tunic of the eyeball, the cornea is, nevertheless, unique in terms of the variety of its functions. Because the cornea differs significantly from other protective frames in its structure, it provides the possibility of light transmission and strong refraction that largely contributes to the total refraction of the eye. The development of ophthalmology is impossible without improving methods of adequate anatomical and functional assessment of the eye not only as a whole, but also as a collection of interacting structures.In this regard, examination methods of the cornea have undergone significant advances in recent years. So far, the level of corneal transparency has been judged by biomicroscopy findings or indirect characteristics (thickness, structure, etc.). Confocal microscopy of the cornea and wave-based examinations involving one of the available laser interferometers (OCT or HRT) are also used. However, the data obtained with these methods resembles that of layer-specific reflectometry, i.e. the magnitude of directed reflection of the light beam from corneal corpuscles, which does not completely agree with the classical idea of transparency.

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Experimental study on the mechanical strain of corneal collagen

Cited by 9 publications

References 26 publications

Imaging of Scleral Collagen Deformation Using Combined Confocal Raman Microspectroscopy and Polarized Light Microscopy Techniques

Imaging of Scleral Collagen Deformation Using Combined Confocal Raman Microspectroscopy and Polarized Light Microscopy Techniques

Biomechanics of Eye Globe and Methods of Its Study

Corneal transparency: anatomical basis and evaluation methods

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