Experimental study on the conduction function of nano-hydroxyapatite artificial bone

Zhu, Weimin; Zhang, X.; Wang, D.; Lü, Wei; Yu-xiang, OU; Han, Yisheng; Zhou, Ke; Liu, H.; Fen, Wenzhe; Peng, Liangquan; He, Cunfu; Zeng, Yitian

doi:10.1049/mnl.2009.0049

Cited by 24 publications

(10 citation statements)

References 7 publications

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“…nHA coatings over distinct metallic implants enhanced fixation and provided better stabilization, bone ingrowth and osteointegration than those of uncoated or μHA‐coated implants (Aksakal, Kom, Tosun, & Demirel, ). Further, the direct implantation of nHA within experimental bone defects significantly enhanced the bone‐formation process, with the deposition of a higher level of mineralized tissue, comparatively to the implantation of μHA (Appleford, Oh, Oh, & Ong, ; Zhu et al, ). The enhanced bioactivity of nHA was further confirmed with the implantation of composites, based on biodegradable polymers and loaded nHA particles, found to outperform those loaded with μHA, with a higher induction of trabecular bone formation within the scaffold structure and at the tissue–scaffold interface (Chung et al, ), as verified in this study.…”

Section: Discussionmentioning

confidence: 99%

Novel cellulose/hydroxyapatite scaffolds for bone tissue regeneration: In vitro and in vivo study

Daugėla

Pranskūnas

Juodžbalys

et al. 2018

J Tissue Eng Regen Med

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Cellulose scaffolds containing nano- or micro-hydroxyapatite (nHA or μHA) were prepared by the regeneration of cellulose from its acetylated derivative and the mechanical immobilization of inorganic particles, followed by freeze-drying. Microtomographic (micro-computed tomography) evaluation revealed that both scaffolds presented a highly interconnected porous structure, with a mean pore diameter of 490 ± 94 and 540 ± 132 μm for cellulose/nHA and cellulose/μHA, respectively. In vitro and in vivo characterizations of the developed scaffolds were investigated. Commercially available bone allograft was used as a control material. For the in vitro characterization, osteoblastic cell cultures were used and characterized over time to evaluate cell adhesion, metabolic activity, and functional output (alkaline phosphatase activity and osteoblastic gene expression). The results revealed greater spreading cell distribution alongside an increased number of filopodia, higher MTT values, and significantly increased expression of osteoblastic genes (Runx-2, alkaline phosphatase, and BMP-2) for cellulose/nHA, compared with cellulose/μHA and the control. The in vivo biocompatibility was evaluated in a rabbit calvarial defect model. The investigated scaffolds were implanted in circular rabbit calvaria defects. Four- and 12-week bone biopsies were investigated using micro-computed tomography and histological analysis. Although both cellulose/HA scaffolds outperformed the assayed control, a significantly higher amount of newly formed mineralized tissue was found within the defects loaded with cellulose/nHA. Within the limitations of this study, the developed cellulose/HA scaffolds showed promising results for bone regeneration applications. The biological response to the scaffold seems to be greatly dependent on the HA particles' characteristics, with cellulose scaffolds loaded with nHA eliciting an enhanced bone response.

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Section: Discussionmentioning

confidence: 99%

Novel cellulose/hydroxyapatite scaffolds for bone tissue regeneration: In vitro and in vivo study

Daugėla

Pranskūnas

Juodžbalys

et al. 2018

J Tissue Eng Regen Med

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“…An allograft is preferred in some cases, but the possible immune response and disease (i.e. human immunodeficiency virus (HIV) or hepatitis B) transmission are detrimental to the recipient [128]. Bone graft substitutes have attracted much attention because of their advantages over both autografts and allografts [129].…”

Section: Bio-orthopedic Properties Of Nanoscale Hapmentioning

confidence: 99%

“…Zhu et al [128] evaluated the osteoconductive properties of nano-HAp material and its potential application as artificial bone in repairing bone defects, and attempted to analyze the scientific basis of these properties. Their animal model of bone defects was based on the bilateral radius of 39 New Zealand white rabbits, which were randomly divided into an experimental group (bone defect repaired with nano-HAp artificial bone), a control group (bone defect repaired with HAp artificial bone) and a blank group (defect left empty).…”

Section: Bio-orthopedic Properties Of Nanoscale Hapmentioning

confidence: 99%

Nanoscale hydroxyapatite particles for bone tissue engineering

2011

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“…Therefore, understanding the relationship between the bone-related cells and nano-sized calcium orthophosphates has been paid much attention in order to elucidate the formation mechanism of bones, to prevent and cure bone-related diseases and to design novel biomaterials. Better structural biomimicity and osteoconductivity can be achieved using nanodimensional and nanocrystalline calcium orthophosphates [178,179,185,186,[660][661][662][663]. Biocompatibility of such biomaterials is the key question for their application possibility for clinical use.…”

Section: Nanodimensional and Nanocrystalline Calcium Orthophosphates mentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Experimental study on the conduction function of nano-hydroxyapatite artificial bone

Cited by 24 publications

References 7 publications

Novel cellulose/hydroxyapatite scaffolds for bone tissue regeneration: In vitro and in vivo study

Novel cellulose/hydroxyapatite scaffolds for bone tissue regeneration: In vitro and in vivo study

Nanoscale hydroxyapatite particles for bone tissue engineering

Nanodimensional and Nanocrystalline Calcium Orthophosphates

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