Experimental Study on the Adsorption of Excess Heparin with Anion Exchange Resin Fiber

Matsuda, Koichi; Oka, Totaro; Tani, Toru; Hanasawa, Kazuyoshi; Yoshioka, Toyokazu; Aoki, Hirohiko; Endo, Yuichi; Ishii, Yutaka; Numa, Kenji; Kodama, Masashi

doi:10.1111/j.1525-1594.1989.tb01570.x

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…Subjects met the diagnostic criteria for OSAHS based on polysomnography (PSG) (adults: AHI ≥5/h; children: AHI ≥1/h) ( 19 , 20 ),…”

Section: Methodsmentioning

confidence: 99%

The correlation of serum/plasma IGF-1 concentrations with obstructive sleep apnea hypopnea syndrome: A meta-analysis and meta-regression

2022

Front. Endocrinol.

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BackgroundObstructive sleep apnea hypopnea syndrome (OSAHS) is a common disease that has serious cardiovascular and metabolic effects. Insulin-like growth factor 1 (IGF-1) levels are reportedly reduced in patients with OSAHS; however, this is still a matter of debate. Therefore, we investigated the association between serum/plasma IGF-1 levels and OSAHS in this meta-analysis.MethodsWan Fang, Excerpta Medica dataBASE, Web of Science, China National Knowledge Infrastructure, VIP, PubMed, and other databases were searched for materials published in any language before April 2, 2022. Two researchers analyzed the studies for quality according to the Newcastle-Ottawa Scale. The acquired data were analyzed using Stata 11.0 and R 3.6.1 software. The effect size was estimated and calculated using standard mean differences and correlation coefficients. Moreover, a combined analysis was conducted using either a random- or fixed-effects model.ResultsUltimately, 34 studies met our inclusion criteria. Our findings revealed that the plasma/serum IGF-1 concentrations in patients with OSAHS was significantly reduced compared with those in healthy subjects. Subgroup analyses were performed according to OSAHS severity, ethnicity, age, body mass index, specimen testing method, and study design. The outcomes suggested that nearly all subgroups of patients with OSAHS had reduced serum IGF-1 levels. Disease severity and differences in ethnicity were identified as possible influencing factors of serum IGF-1 levels in patients with OSAHS in the meta-regression analysis, and no other factors were found to alter plasma/serum IGF-1 concentrations. Moreover, plasma/serum IGF-1 concentrations were negatively correlated with apnea-hypopnea index and oxygen desaturation index scores and positively associated with minimum oxygen saturation.ConclusionSerum/plasma IGF-1 concentrations in patients with OSAHS were greatly reduced compared with those of patients in the control group, and were negatively correlated with apnea-hypopnea index and oxygen desaturation index scores and positively correlated with minimum oxygen saturation.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022322738.

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“…Subjects met the diagnostic criteria for OSAHS based on polysomnography (PSG) (adults: AHI ≥5/h; children: AHI ≥1/h) ( 19 , 20 ),…”

Section: Methodsmentioning

confidence: 99%

The correlation of serum/plasma IGF-1 concentrations with obstructive sleep apnea hypopnea syndrome: A meta-analysis and meta-regression

2022

Front. Endocrinol.

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“…It would, therefore, be highly unlikely if this chemically potent drug did not interact with foreign surfaces. Indeed, binding and immobilization of anticoagulants such as heparin or nafamostat mesilate (FUT) onto dialysis membranes has been the target of much research over the last 20 years (e.g., [45][46][47][48][49][50][51]. Apart from influencing the anticoaguiatory properties of extracorporeal materials, it can be assumed that this layer coating of immobilized anticoagulants should affect surface biocompatibility (51).…”

Section: Heparinmentioning

confidence: 99%