The seismic behavior of plane moment-resisting frames (MRFs) consisting of I steel beams and concretefilled steel tube (CFT) columns is investigated in this study. More specifically, the effect of modeling details of each individual component of CFT-MRFs, such as the composite CFT columns, the beam-column connections, the panel zones, and the steel I beams on their seismic behavior, is studied through comparisons against available experimental results. Then, fragility curves are constructed for three typical CFT-MRFs, designed according to European codes, for various levels of modeling sophistication through nonlinear time-history analyses. On the basis of these fragility curves, one can select the appropriate modeling level of sophistication that can lead to the desired seismic behavior for a given seismic intensity.with the beams designed to remain elastic. Local buckling occurred at the base of the columns, leading to strength degradation. They concluded that these CFT-MRFs showed better hysteretic characteristics than a weak-beam strong-column MRF with wide flange steel columns. Chen et al. [15] performed pseudodynamic tests on a full-scale three-bay composite frame, which included a braced frame in the central bay and moment connection between steel beams and CFT columns in the exterior bays. The study reported that the presence of the braces limited the inelastic demand imposed on the moment connections and that most of the energy was dissipated by the buckling restrained braces, with only minor yielding observed in all the moment connections. Herrera et al.[16] conducted pseudodynamic tests on approximately half scale of a two-bay four-story composite MRF with a basement level, using performance-based design concepts. A weak-beam strong-column concept in the design and a spilt tee beam-to-column moment connection were used to enable plastic hinges to form in the beams. The test structure response was consistent with the expected performance for all seismic input levels, indicating that a very good seismic performance of composite MRFs with CFT columns can be achieved. Tsai et al. [17] conducted tests on a full-scale three-story, three-bay CFT buckling restrained braced frame. Square CFTs were used for the two exterior columns and circular CFTs for the two center columns. Three types of moment connections were used in the exterior beam-column connections, specifically through beam, external diaphragm, and bolted end-plate connections. A series of six pseudodynamic tests were conducted subjecting the frame to ground motions of various intensities, and then, a quasi-static cyclic load protocol was applied until fracture of the braces. The braces were replaced, and another series of pseudodynamic tests were performed. Vibration tests were conducted after each pseudo dynamic test to measure the changes in stiffness and damping, and only minor changes were observed.Besides the experiments, there have been reported numerous analytical studies in the literature on CFT-MRFs components and systems, including column...