2-Ethylhexanol is a versatile platform chemical with extensive applications in various elds. Currently, 2ethylhexanol is exclusively produced from petroleum resources. However, the increased market demand for it and the depletion of fossil resources would entail the production of 2-ethylhexanol in a more sustainable way. Production of 2-ethylhexanol from renewable lignocellulosic biomass could be an alternative pathway. Here, we reviewed the applications of 2-ethylhexanol in different elds, with a focus on the renewable production of bio-based fuels, plasticizer, lubricant and surfactant from 2-ethylhexanol. Moreover, the possible pathways for renewable production of 2-ethylhexanol from lignocellulosic biomass are also discussed. Finally, future perspectives on renewable production of 2-ethylhexanol are also provided.