This paper describes the effect of the tool tilting angle on the tool wear and the surface roughness in micro ball end milling. The cutting tests of hardened stainless steel were carried out by using of the micro ball end mill with radius of 100mm under the conditions of tilting angle from 0° to 45°. The spindle speed was fixed in a constant of 120,000 min-1. The feed per tooth, axial depth of cut and radial depth of cut were also fixed. The flank wear, the surface roughness and the cutting force were investigated. As a result, the maximum width of flank wear of the micro ball end mill tended to decrease with an increase in the tilting angle of spindle. The surface roughness became almost constant not depending on the tilting angle of the spindle.