Experimental and numerical analysis is arranged with exergy destruction to evaluate thermal performance of system on nanofluid flow in tube with single and double strip helical screw inserts at different values of twist ratio in laminar flow regime. CFD analysis has occurred on the fluent workbench of ANSYS software. The Nusselt number attained enhancement with the flow of nanofluid in double strip helical screw inserts as compared with single strip helical screw inserts at decreasing values of twist ratio and increasing values of Reynolds number. Maximum enhancement of 421% is found with Nusselt number in the flow of nanofluid in tube with double strip helical screw insert at 1.5 of twist ratio and lower value of Reynolds number as compared with the flow of water in plain tube. Common correlations of Nusselt number and friction factor are generated. Exergy destruction number is attained less than one value for both types of inserts at different values of twist ratio and Reynolds number, whereas attained lower value with the flow of nanofluid in tube with double strip helical screw insert at twist ratio of 1.5 and low value of Reynolds number. Heat transfer enhancement number is attained more than one value for both types of inserts with different values of twist ratio and Reynolds number, whereas double strip helical screw inserts attained maximum value at twist ratio of 1.5 in the range of Reynolds number. Therefore, double strip helical screw inserts are the best inserts as compared with single strip helical screw inserts to compact the size of heat exchangers, whereby size of many thermal applications could be compact such as solar water heater, electronic cooling devices, automobile radiator, power plants etc.