Experimental study on inhibition of rat ventricular Ik1 by RNA interference targeting the KCNJ2 gene

Hu, Bin; Zhu, Xiaolong; Fan, Qin; Li, Hongxin

doi:10.5582/bst.2012.v6.1.26

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…The consistent conclusions are also drawn in other biological experiments. By suppressing I K1 in the newborn Wistar rats' ventricle, Hu et al observed the increasing beating frequency which was in accordance with their hypothesis that the ventricular myocytes could be converted into pacing cells by the inhibition of I K1 [25]. In the experiment of Kapoor et al, they found that when I K1 was substantially reduced, the ventricular myocytes were converted into the SAN cells and ectopic pacemaker activities were detected in the ventricle [26].…”

Section: Introductionmentioning

confidence: 58%

“…As a consequence, we modulate the currents by adjusting their corresponding maximal conductance in the simulation. In particular, because the nonautomatic ventricular myocytes could be converted into pacing cells by reducing I K1 [21][22][23][24][25][26], we derive the pacing cell model by depressing G K1 , the maximal conductance of I K1 .…”

Section: Models and Methodsmentioning

confidence: 99%

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A Simulation Study on the Pacing and Driving of the Biological Pacemaker

Zhang

Wang

et al. 2020

BioMed Research International

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The research on the biological pacemaker has been very active in recent years. And turning nonautomatic ventricular cells into pacemaking cells is believed to hold the key to making a biological pacemaker. In the study, the inward-rectifier K+ current (IK1) is depressed to induce the automaticity of the ventricular myocyte, and then, the effects of the other membrane ion currents on the automaticity are analyzed. It is discovered that the L-type calcium current (ICaL) plays a major part in the rapid depolarization of the action potential (AP). A small enough ICaL would lead to the failure of the automaticity of the ventricular myocyte. Meanwhile, the background sodium current (IbNa), the background calcium current (IbCa), and the Na+/Ca2+ exchanger current (INaCa) contribute significantly to the slow depolarization, indicating that these currents are the main supplementary power of the pacing induced by depressing IK1, while in the 2D simulation, we find that the weak electrical coupling plays a more important role in the driving of a biological pacemaker.

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Section: Introductionmentioning

confidence: 58%

Section: Models and Methodsmentioning

confidence: 99%

A Simulation Study on the Pacing and Driving of the Biological Pacemaker

Zhang

Wang

et al. 2020

BioMed Research International

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Cardiovascular adverse effects and mechanistic insights of arsenic exposure: a review

Wāng,

Ma,

Wang

et al. 2024

Environ Chem Lett

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Design, synthesis and biological evaluation of 4-chromanone derivatives as IKr inhibitors

Wang

Liu

et al. 2014

DD&T

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Cardiac arrhythmia is a major cause of death in the world. Among many delayed rectifier potassium currents, the rapid delayed rectifier K current (IKr) plays an important role in the repolarization of cardiac tissue. The inhibition of IKr can delay repolarization and lead to an increase in the QT interval of the electrocardiogram, which is the treatment mechanism of Class III antiarrhythmic agents. Therefore, IKr can be considered as the drug target for the treatment of cardiac arrhythmia. In the current study, a series of 4-chromanone compounds (WR1-WR12) were well designed and synthesized as IKr inhibitors. The results disclosed that two compounds displayed potent inhibitory activities against IKr. Moreover, our structure-activity relationship results might provide necessary information for the rational design of inhibitors for IKr.

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Experimental study on inhibition of rat ventricular Ik1 by RNA interference targeting the KCNJ2 gene

Cited by 3 publications

References 24 publications

A Simulation Study on the Pacing and Driving of the Biological Pacemaker

A Simulation Study on the Pacing and Driving of the Biological Pacemaker

Cardiovascular adverse effects and mechanistic insights of arsenic exposure: a review

Design, synthesis and biological evaluation of 4-chromanone derivatives as IKr inhibitors

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