Experimental study on antinociceptive and anti-allergy effects of patchouli oil

Abstract

Pogostemon cablin (Blanco) Benth. (Lamiaceae), which is named 'Guang-Huo-Xiang' in Chinese, has various therapeutic functions to remove dampness, relieve summer-heat and exterior syndrome, stop vomiting, and stimulate appetite. Patchouli oil is the essential oil of Pogostemonis herba. This study is aimed to investigate the antinociceptive and anti-allergy activities of patchouli oil. The antinociceptive activity of patchouli oil (20, 40, and 80 mg/kg) was evaluated using the acetic acid-induced writhing test (NIH mice) and the hot-plate test (NIH mice), and those for anti-allergy activity were tested using Schultz-Dale reaction, the passive cutaneous anaphylaxis (PCA) test, and delayed-type hypersensitivity (DTH) test. All doses of patchouli oil could significantly (p<0.05) extend writhing latent period and moderately decrease writhing frequency. In the hot-plate test, patchouli oil treatment significantly (p<0.01) increased the latency period at all three doses at 30, 60, and 90-minute time intervals compared with the control group. Patchouli oil could remarkably (p<0.01) inhibit the contraction induced by the Schultz-Dale reaction. Moreover, patchouli oil at all doses significantly (p<0.01) inhibited the PCA reaction induced by Sprague-Dawley rat anti-ovalbumin serum and the DTH reaction induced by the 2,4-dinitrochlorobenzene when comparing with those of the control group. The findings suggested that patchouli oil may provide additional evidence for its potential uses as antinociceptive and anti-allergy agents.

Patchouli Essential Oil and Its Derived Compounds Revealed Prebiotic-Like Effects in C57BL/6J Mice

“…Patchouli is a traditional Chinese medicine for the treatment of gastrointestinal symptoms. PEO and its derived compounds PA, PO, and β-PAE are the main active ingredients of patchouli that possess anti-inflammation, anti-oxidant, anti-microbial, anti-allergy, and anti-cancer effects based on the cellular and animal studies (Li et al, 2011; He et al, 2013; Jeong et al, 2013; Dechayont et al, 2017). It is our interest to investigate whether the commensal GM plays a role in the health benefits of patchouli.…”

A Comprehensive Review on the Phytochemical Constituents and Pharmacological Activities of Pogostemon cablin Benth.: An Aromatic Medicinal Plant of Industrial Importance

“…Xinxiang granule (XXG) is prepared from Biond magnolia flowers ( Magnolia biondii ), patchouli herb and small centipeda herb ( Centipeda minima ) and is used to treat allergic rhinitis and passive skin irritability [108]. Recently, the potential uses of patchouli oil for its antinociceptive and anti-allergic activities were confirmed in mouse models [109].…”

A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4/Nuclear Factor-κB

“…And most of the identified compounds in YJH sample including chlorogenic acid, galuteolin, linarin, luteolin, apigenin, patchoulol alcohol, pogostone, germacrone, curdione, and furanodiene have been reported to exhibit significant inflammatory effects [ 18 , 28 , 30 – 33 , 48 ]. Most importantly, our previous researches revealed that patchouli alcohol, the largest ingredient of YJH, had remarkable anti-inflammatory activity and would protect mice against the lung injury in mice of viral infection and influenza model [ 18 , 21 – 23 , 25 – 27 , 33 , 48 ]. Thus, the chemical analysis of YJH suggested that these major components are possibly responsible for the regulation of inflammatory factors against inflammation response in LPS induced ALI.…”

“…It has been reported to have antioxidant, antinociceptive, antiallergy, antibacterial, and antirespiratory virus actions [ 26 – 29 ]. The chemistry profiles of PO indicated that patchoulol alcohol and pogostone are the two most components in it [ 27 , 28 ]. Previous studied also demonstrated that patchouli alcohol could significantly prevent LPS-induced ALI in mice [ 30 – 33 ].…”