Experimental study of the stirring conditions taking place in a pilot plant continuous mixer of particulate solids

Marikh, Khadija; Berthiaux, Henri; Mizonov, Vadim E.; Barantseva, Elena

doi:10.1016/j.powtec.2005.05.020

Cited by 41 publications

(22 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 shows the modelling and experimental results obtained for double-step perturbations on the inflow rate. While there are still some discrepancies in the probability P 21 , very good agreement is obtained for the hold-up weight and the outflow rate. As previously, the model is more predictive on the outflow rate.…”

Section: Flow-rate Perturbationsmentioning

confidence: 70%

“…The transitory evolution of the hold-up during the perturbations towards lower (positive steps) or higher (negative steps) values is respectively traduced by periods of higher or lower values of the outflow rate. This gives rise to upward or downward peaks in outflow rate, as well as in probability P 21 , which are accurately depicted by the markovian model. Fig.…”

Section: Modelling Strong Perturbationsmentioning

confidence: 71%

“…2). Full description of the equipment can be found in Marikh et al [21,22]. The mixer itself is a hemi-cylindrical tank of 50 cm in length, 16.5 cm in height and 20 cm in diameter (see Fig.…”

Section: Experimental Set Up and Methodsmentioning

confidence: 99%

“…In order to determine a relation between the transition matrix P and the state of the system (M 1 and M 2 ), the evolution of the probability P 21 according to the hold-up weight M 1 has been represented in Fig. 7.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Predicting bulk powder flow dynamics in a continuous mixer operating in transitory regimes

Ammarcha

Gatumel

Dirion

et al. 2012

Advanced Powder Technology

Self Cite

View full text Add to dashboard Cite

OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. This is an author-deposited version published in : http://oatao.univ-toulouse.fr/ Eprints ID : 9970 a b s t r a c tOver recent years there has been increasing interest in continuous powder mixing processes, due mainly to the development of on-line measurement techniques. However, our understanding of these processes remains limited, particularly with regard to their flow and mixing dynamics. In the present work, we study the behaviour of a pilot-scale continuous mixer during transitory regimes, in terms of hold-up weight and outflow changes. We present and discuss experimental results concerning the start-up dynamics of a Gericke GCM 500 mixer, for which a specific experimental protocol has been developed to determine the evolution of the hold-up in the mixer and the real outflow. Empirical relationships are derived so as to link hold-up weight variations with operating conditions. A simple stochastic approach, based on a non-homogeneous Markov chain, is developed to simulate the bulk particle flow and transport in the continuous mixer at a macroscopic level. Although this simple model is only based on the start-up behaviour, it provides a full description of the mixer dynamics in response to strong perturbations on the flow rate or on the rotational speed of the stirring device, such as negative or positive steps. This model is validated experimentally for a wide range of operating conditions, and constitutes a first approach to process control.

show abstract

Section: Flow-rate Perturbationsmentioning

confidence: 70%

Section: Modelling Strong Perturbationsmentioning

confidence: 71%

Section: Experimental Set Up and Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Predicting bulk powder flow dynamics in a continuous mixer operating in transitory regimes

Ammarcha

Gatumel

Dirion

et al. 2012

Advanced Powder Technology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The effect of operating parameters and powder properties on mixing performance within continuous convective blenders has been studied extensively [35][36][37][38][39]41,45]. Marikh et al [36,45] have studied the influence of mass flow rate, impeller speed and bulk powder properties on the hold up within a pilot-scale continuous mixer for different agitator types.…”

Section: Continuous Mixersmentioning

confidence: 99%

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

2013

View full text Add to dashboard Cite

Abstract:The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models for solids-handling unit operations. Continuous processing is of particular interest in the current study because it has the potential to improve the efficiency and robustness of pharmaceutical manufacturing processes.

show abstract

Continuous Processing in Secondary Production

Warman

2010

Chemical Engineering in the Pharmaceutical Industry

View full text Add to dashboard Cite

Experimental study of the stirring conditions taking place in a pilot plant continuous mixer of particulate solids

Cited by 41 publications

References 3 publications

Predicting bulk powder flow dynamics in a continuous mixer operating in transitory regimes

Predicting bulk powder flow dynamics in a continuous mixer operating in transitory regimes

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

Continuous Processing in Secondary Production

Contact Info

Product

Resources

About