Experimental study of the mechanical behavior of an explanted mesh: The influence of healing

Squid Ring Teeth–coated Mesh Improves Abdominal Wall Repair

“…SRT binds to abdominal wall proteins, while not relying on the typical inflammatory process of scar formation. 20 High mechanical properties (ie, elastic modulus of 2–4 GPa and strength of 50–100 MPa) and significantly less craniocaudal shrinkage were seen compared with uncoated PP mesh. These unique properties may allow it to function better than other synthetic and biologic meshes, which can experience significant shrinkage 21 or increased recurrence rates, 22 respectively, as demonstrated in both animal studies and clinically.…”

Squid Ring Teeth Coated Mesh Improves Abdominal Wall Repair

“…In our study, we demonstrated that a thin SRT coating increases the strength of the meshtissue interface in an inlay repair without any increase in inflammation. The SRT protein binds with abdominal wall proteins, while not relying on the typical inflammatory process of scar formation (36). High mechanical properties (i.e., elastic modulus of 2-4 GPa and strength of 50-100MPa) and enhanced tissue integration of SRT further helped to result in significantly less cranio-caudal shrinkage compared to uncoated PP mesh.…”

Biomechanical Modeling of Prosthetic Mesh and Human Tissue Surrogate Interaction

“…Clinically, mesh implantation has been observed to lead to several short-term and long-term problems due to differences in the mechanical properties of the mesh, suture, and native tissue [12]. A typical mesh implantation procedure involves the development of scar tissue, which, over a few weeks, grows through the mesh and subsequently integrates with it to form a new composite made of the native tissue, the mesh implant, and the scar tissues [25]. In this study, the primary focus was to understand the short-term effects of the mesh implantation procedure.…”