Experimental Study of Taurine on the Cerebral Dehydrogenase Activity in the Model of Unilateral Cerebral Ischemia

Макарова, Л. М.; Pogoreliy, V. E.; Новикова, Н. А.; Oleynikova, Olga; Makarova, Tamara I.

doi:10.1007/978-3-319-15126-7_42

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“…Calculation of standard bicarbonate (SB), the sum of buffer bases (BB), and the shift (excess or deficit) of buffer bases (BE) was performed according to the Siggaard-Andersen nomogram. Arterial blood was taken from the common carotid artery; venous blood was taken from the sagittal sinus (37).…”

Section: Methodsmentioning

confidence: 99%

“…The search for effective medicines for treating ischemic brain damage is an urgent task of modern science. The prospects for using taurine (5,6), resveratrol (7), and glycine (8) as neuroprotectors are shown. In the same way, Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride (9), melatonin (7), hydroxymethylethylpyridine succinate, nicotinoyl gamma-aminobutyric acid, nimodipine, amlodipine besylate and S-amlodipine nicotinate (10), apovincaminic acid derivative (11), glutamic acid (12), magnesium sulfate (13), as well as herbal remedies -Rhodiola rosea (14), Astragalus membranous (7) and preparations of animal origin -cortexin, cerebrolysin, actovegin (15) and other compounds.…”

Section: Introductionmentioning

confidence: 99%

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Study of the Effects of Vinpocetine on Indicators of Acid-Alkaline State Following the Ischemic Brain Damage

Макарова

Pogorely

Abisalova

et al. 2023

Infarma

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Vinpocetine is a multipurpose medicine with several pharmacological targets. It is known for its neuroprotective properties. Its mechanism of action in brain pathology is due to a selective inhibitor of phosphodiesterase type 1, inhibition of voltage-gated sodium channels, and a decrease in calcium influx into neurons. Vinpocetine combines high clinical efficacy and safety of use. Therefore it successfully competes in the pharmaceutical market with an ever-increasing number of new medicines. The purpose of the work was to experimentally study the effects of vinpocetine in cats at a dose of 5 mg/kg on the indicators of the acid-base state (ABS) of arterial and venous blood in the simulation of total cerebral ischemia. The effect of vinpocetine on acid-base status indicators should be considered as the most important aspect of its action, contributing to the neuroprotective effect. The paper discusses possible molecular targets and mechanisms for implementing the protective effect of vinpocetine in ischemia, considering its favorable effect on ABS. These new findings may point to increased use of vinpocetine in human cardiovascular diseases accompanied by ABS deterioration.

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Section: Methodsmentioning

confidence: 99%