Experimental Study of Poly-l-Lactic Acid Biodegradable Stents in Normal Canine Bile Ducts

Yamamoto, K; Yoshioka, Tetsuya; Furuichi, Kinya; Sakaguchi, Hiroshi; Anai, Hiroshi; Tanaka, Toshihiro; Morimoto, Kengo; Uchida, Hideo; Kichikawa, Kimihiko

doi:10.1007/s00270-010-0045-2

Cited by 38 publications

(22 citation statements)

References 13 publications

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“…If the stent was patent up to 6 months after insertion, the authors described endothelial proliferation or embedding of the stent in 75% of the cases. Moreover, stent fragmentation was seen in all stents retrieved at the end of the study (9 months) [75].…”

Section: Bioabsorbable Stentsmentioning

confidence: 98%

Novel biliary self-expanding metal stents: indications and applications

Bléro

Huberty

Devière

2014

Expert Review of Gastroenterology & Hepatology

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Endoscopic insertion of a self-expanding metal stent (SEMS) through a malignant common bile duct stricture is the first line of palliation for malignant jaundice. Patency of these stents remains a major concern. SEMS dysfunction can result from tumor ingrowth, overgrowth and/or clogging. Initial SEMS modifications involved covering the central part of the stent in order to reduce ingrowth and ultimately increase patency. Fully covered stents became available shortly after reports of their use in human patients. The potential removability and radial strength of SEMS have led to evaluation of their use in new indications including benign biliary strictures, post sphincterotomy bleeding and perforation. Other aspects of development include the addition of features such as anti-reflux valves, drug elution and spontaneous biodegradability. These aspects and their clinical implications are reviewed and discussed.

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Section: Bioabsorbable Stentsmentioning

confidence: 98%

Novel biliary self-expanding metal stents: indications and applications

Bléro

Huberty

Devière

2014

Expert Review of Gastroenterology & Hepatology

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“…Bioabsorbable stent is still in laboratory stages, without clinical use so far 39-42. It is noteworthy that recently a research team in Finland has gained an unparalleled position in this field when they reported the results of a phase 1 clinical study after long and hard work in animal tests 43…”

Section: Studies For Functional Stentmentioning

confidence: 99%

Functional Self-Expandable Metal Stents in Biliary Obstruction

Kwon

Hahm

et al. 2013

Clin Endosc

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Biliary stents are widely used not only for palliative treatment of malignant biliary obstruction but also for benign biliary diseases. Each plastic stent or self-expandable metal stent (SEMS) has its own advantages, and a proper stent should be selected carefully for individual condition. To compensate and overcome several drawbacks of SEMS, functional self-expandable metal stent (FSEMS) has been developed with much progress so far. This article looks into the outcomes and defects of each stent type for benign biliary stricture and describes newly introduced FSEMSs according to their functional categories.

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“…No gross degradation was seen at 1, 3, or 6 months, but fragmentation had started at 9 months when the stents were removed. 31 Haber et al demonstrated safe deployment of a 10 mm674 mm bioabsorbable poly-L-lactide stent in 48 of 50 patients with malignant biliary obstruction. 32 Notably, radial compliance force was reduced by 60% in this stent relative to plastic stents.…”

Section: Bioabsorbable Stentsmentioning

confidence: 99%

“…Yamamoto et al investigated a biodegradable 6 mm615 mm poly-L-lactic acid Z pattern stent with platinum markers and placed them in 12 dogs. 31 Cholangiography and laparotomy were performed at 1, 3, 6, and 9 months, and the stents remained patent throughout. Endothelial ingrowth into the wall was seen in nine of 12 dogs.…”

Section: Bioabsorbable Stentsmentioning

confidence: 99%

An Update to Hepatobiliary Stents

Moy¹,

Bir²

2015

JCTH

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Endoscopic stent placement is a common primary management therapy for benign and malignant biliary strictures. However, continuous use of stents is limited by occlusion and migration. Stent technology has evolved significantly over the past two decades to reduce these problems. The purpose of this article is to review current guidelines in managing malignant and benign biliary obstructions, current endoscopic techniques for stent placement, and emerging stent technology. What began as a simple plastic stent technology has evolved significantly to include uncovered, partially covered, and fully covered self-expanding metal stents (SEMS) as well as magnetic, bioabsorbable, drug-eluting, and antireflux stents.

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Experimental Study of Poly-l-Lactic Acid Biodegradable Stents in Normal Canine Bile Ducts

Abstract: Our results suggest that PLLA bioabsorbable stents seems to be useful for implantation in the biliary system with further investigation.

Cited by 38 publications

References 13 publications

Novel biliary self-expanding metal stents: indications and applications

Novel biliary self-expanding metal stents: indications and applications

Functional Self-Expandable Metal Stents in Biliary Obstruction

An Update to Hepatobiliary Stents

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