The current rise in insecticide resistance of mosquitoes to synthetic compounds that used to be very effective is of great concern to malaria control. Several bio-compounds from plants and essential oils have insecticidal or repellent potencies. However, lack of harmonization and complete research on insecticides from plant origin have obscured the breakthrough of discovering an alternative plant-based mosquito repellent to the synthetic DEET-based repellents. This review seeks to provoke the drive for finding an alternative and effective mosquito repellent from plants or essential oil sources with focus on Azadirachta indica and Citrus sinensis.