Experimental study of epithelialization of the muscle-only flap in the oral cavity

Elshal, Elsherbini Elazazy; Inokuchi, Tsugio; Sekine, Joji; Sano, Kazuo

doi:10.1016/s0278-2391(97)90643-1

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…In particular, there is a disappearance of myofibroblast through apoptosis (8,23). These events have also been observed in the healing process of the muscle flap in the oral cavity (5,6).…”

Section: Discussionmentioning

confidence: 89%

“…The disadvantage of this type of flap is that it undergoes significant contraction postoperatively. The reason for this phenomenon is not well-understood, but it has been demonstrated in a number of reports that myofibroblast, which has features of contractile fibers such as alpha smooth muscle actin (a-SMA), participates in flap contraction (5,6) and that the disappearance of myofibroblast that occurs through apoptosis is responsible for wound contraction (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Study on Wound Healing of a Muscle Flap Transferred into the Oral Cavity of Rats.

Tobita

Inokuchi

2001

Oral Med Pathol

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The immunohistochemical expressions of FGF2, FGFR1, FGFR2, and their possible participation in the apoptosis of myofibroblast were studied in the healing process of a muscle flap transferred into the oral cavity of rats. At 14 days postoperatively, abundant myofibroblasts were observed in the early-granulating muscle flap, and at 18 days postoperatively, they began to gradually disappear. The FGF2 immunopositive area, the number of FGFR2-positive fibroblasts and TUNEL-positive fibroblasts reached a maximum at 18 days postoperatively and gradually decreased thereafter, and there was a significant correlation of expression between the FGFR2positive fibroblast and TUNEL-positive fibroblast. On the other hand, FGFR1-positive fibroblasts were observed from day 10 to 21 in the granulation tissue formation of the muscle flap. These findings suggest that FGFR1 may participate as a factor affecting tissue remodeling of muscle flap healing, and that FGFR2 may play a role in programmed cell death or apoptosis of myofibroblast.

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“…In particular, there is a disappearance of myofibroblast through apoptosis (8,23). These events have also been observed in the healing process of the muscle flap in the oral cavity (5,6).…”

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Study on Wound Healing of a Muscle Flap Transferred into the Oral Cavity of Rats.

Tobita

Inokuchi

2001

Oral Med Pathol

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“…Epithelization of the intraoral muscle flaps in experimental models showed muscle atrophy, fibrosis, and complete mucosal coverage by 8 weeks. 16,19 Although atrophy and fibrosis is a disadvantage in mobile areas like the tongue, floor of the mouth, and buccal areas, it provides an advantage for resurfacing the hard palate and dental alveolar mucosa. These structural changes enable durable support, limited bulk, and adherence to surrounding and underlying bone and enables the use of dental implants to a greater degree than skin flaps, resembling the native oral tissues.…”

Section: Discussionmentioning

confidence: 99%

Free Segmental Vastus Lateralis Muscle Flap for Reconstruction of Recalcitrant Defects of the Cleft Hard Palate

Acartürk

2012

J reconstr Microsurg

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“…In the previous study, we showed that the muscle-only flap heals with secondary epithelialization in the oral cavity, in a way similar to the mucosa. However, the flap matures to fibrous tissue with resultant severe contraction 4,1 . This biological behavior of the muscle-only flap may indicate the limitation of its applicability, suggesting that its best use is for mucosal defects in the osseous region 1 .…”

Section: Discussionmentioning

confidence: 99%

“…A muscle-only flap has been used for reconstruction of the oral cavity because it heals with secondary epithelialization, mimicking the oral mucosa [1][2][3] . However, cicatricial contraction remains an issue for the muscle-only flap 4,5 . In a previous study, we showed that fascial flaps heal with secondary epithelialization with mild contraction 5 .…”

Section: Introductionmentioning

confidence: 99%

Myodermal Flap for Reconstruction of Oral Mucosa

Uehara

Inokuchi

Ikeda

et al. 2008

Journal of Oral and Maxillofacial Surgery

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1 Abstract PurposeMyocutaneous flaps were commonly used to repair the mucosal defect that results from ablative tumor surgery. However, skin is not a perfect substitute for the oral mucosa because it can lead to poor hygiene due to hair growth and desquamation. The myodermal flaps used for the reconstruction of mucosa in oncologic surgery of the oral cavity. Material and methodPectoralis major and platysma myodermal flaps were applied in 8 patients for the purpose of intraoral reconstruction in cancer surgery. The skin paddle of the flaps denuded by shaving the epithelial layer was transferred into the oral cavity to cover the mucosal defect. ResultThe flaps epithelialized secondarily without severe contraction. ConclusionThe myodermal flap is a promising option for reconstruction of the oral mucosa.2

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Experimental study of epithelialization of the muscle-only flap in the oral cavity

Cited by 7 publications

References 25 publications

Immunohistochemical Study on Wound Healing of a Muscle Flap Transferred into the Oral Cavity of Rats.

Immunohistochemical Study on Wound Healing of a Muscle Flap Transferred into the Oral Cavity of Rats.

Free Segmental Vastus Lateralis Muscle Flap for Reconstruction of Recalcitrant Defects of the Cleft Hard Palate

Myodermal Flap for Reconstruction of Oral Mucosa

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