Experimental study of electrolysis-induced hepatic necrosis

Robertson, G. S. M.; Wemyss‐Holden, Simon A.; Dennison, Ashley R.; Hall, Pauline de la Μ.; Baxter, P S; Maddern, Guy J.

doi:10.1046/j.1365-2168.1998.00806.x

Cited by 51 publications

(66 citation statements)

References 28 publications

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“…Direct current is passed along electrode catheters which have exposed platinum electrodes. The catheters are inserted directly into the tumour under intra-operative ultrasound control and the duration of treatment calculated from a dose-response curve from previous animal experiments [12, 13]. Tissue necrosis is caused by the production of chlorine gas and hydrogen ions at the anode and hydrogen gas and sodium hydroxide at the cathode [14]thereby creating a pH gradient.…”

Section: Discussionmentioning

confidence: 99%

Electrolytic Ablation of Colorectal Liver Metastases: 1-Year Histological Patient Follow-Up

et al. 2000

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Whilst up to 50% of patients with colorectal carcinoma will develop liver metastases, only 20% of those patients will be amenable to potentially curative liver resection. There is therefore great need for other effective therapies, and we report complete ablation of a colorectal liver metastasis using electrolysis, which was histologically confirmed at 1 year. The clinical impact of complete tumour ablation at 1 year means that a proportion of those patients currently deemed inoperable and therefore incurable, may be suitable for curative treatment.

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Section: Discussionmentioning

confidence: 99%

Electrolytic Ablation of Colorectal Liver Metastases: 1-Year Histological Patient Follow-Up

et al. 2000

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“…In a previous study in the normal rat liver [29], it tumour cells were cultured on microspheres and injected into the portal vein. This technique resulted in the growth was shown that in the majority of cases, the 'primary' electrolytic hepatic lesion was associated with a 'secondof multiple, discrete liver tumours.…”

Section: Discussionmentioning

confidence: 99%

“…In each rat only one tumour normal rat liver ( fig. 2) [29] by examining various comwas treated; the untreated tumour acted as the animal's binations of coulombs and milliamps and the resulting own control. Two weeks after tumour implantation and lesion size in the rat liver.…”

Section: Methodsmentioning

confidence: 99%

“…Our previous studies [21,29] have shown that electrolysis is a safe, controllable and predictable method for Tumour Growth Rate A pilot study was performed to establish the growth creating discrete areas of hepatic necrosis in the normal liver of the rat. Electrode separation affects the total vol-rate of the tumour and hence the most appropriate time for treatment after tumour implantation (as judged by ume of hepatic necrosis and in the majority of rats in this study, a wedge of 'secondary' ischaemic necrosis was the size of the tumour deposits).…”

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confidence: 99%

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Electrolytic Treatment of Colorectal Liver Tumour Deposits in a Rat Model: A Technique with Potential for Patients with Unresectable Liver Tumours

Wemyss‐Holden¹,

Robertson²,

Hall³

et al. 2000

Dig Dis

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Background/Aims: Patients with unresectable malignant liver tumours have a poor prognosis. A technique is needed which improves long-term survival. Previous studies in the rat have shown that electrolysis is a safe, predictable and reproducible method for creating areas of necrosis in the normal rat liver. This study examined the effects of electrolysis on colorectal liver ‘metastases’ in the rat. Methods: Tumours of colorectal origin were implanted into the livers of Wistar-WAG rats. Two weeks after implantation the tumours were treated with electrolysis. A direct current generator, connected to 2 platinum intrahepatic electrodes was used to examine the effects of various electrode configurations on the extent of tumour necrosis. Results: Significant (p<0.001) tumour ablation was achieved with all electrode configurations. Tumour necrosis was more complete (p<0.05) with the electrodes positioned on either side of the tumour than with both electrodes placed in the centre of the tumour. Liver enzymes (AST and ALT) were significantly (p<0.001) elevated after treatment, but returned towards normal by 2 days. Conclusions: This study has shown that colorectal liver ‘metastasis’ can be ablated by electrolysis in a rat model. Two separate mechanisms of tumour ablation were observed: With the electrodes directly in or adjacent to the tumour, necrosis resulted from the action of cytotoxic electrode products, whereas by positioning the electrodes proximal to the tumour, necrosis was induced by a ‘secondary’ ischaemic effect. The findings confirm the view that electrolysis has great potential for treating patients with unresectable malignant liver tumours.

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“…At 24 hours after the application showed a significant increase in serum aspartate aminotransferase and alanine aminotransferase, both markers of cell damage. (17) It believed that Achilles tendinopathy pain is related to a process of degeneration of the tissue, to be reduced or ceased as tissue repair. Tissue repair is a dynamic state comprising different processes, including inflammation, cell proliferation and synthesis of the elements that constitute the extracellular matrix, such as collagen, elastin, and reticulin.…”

Section: Application Of Percutaneous Microeletrólisis (Mep®)mentioning

confidence: 99%

Effects of Microelectrólisis Percutaneous (MEP ®) on pain and functionality in patients with calcaneal tendinopathy.

Silva¹,

Costa²,

Coldibeli³

et al. 2014

mtprehabjournal

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Introduction: The Achilles tendinopathy with tendon injuries are the third most common in the musculoskeletal system. New therapies have been proposed for the treatment of tendinopathy as Percutaneous Microelectrólisis (MEP ®). Objectives: The aim of this study was to evaluate the effects of MEP ® on tendinopathy of Achilles. Method: This was a controlled clinical trial, randomized study. The sample comprised 20 patients with Achilles tendinopathy. The volunteers were randomly divided into two groups, control (G1) underwent conventional treatment protocol and experimental (G2) which was under the application of MEP. We made two visits per week for a month, totaling eight sessions. As evaluation method were used four questions from Visa-A questionnaire related to the functionality and exercise pratice. Data were analyzed using paired and independent T test. Results: The pain when walking down stairs has been observed a reduction in G1 (p <0.05) and G2 (p <0.001) before and after the protocols. Among the groups there was a greater reduction in G2 (p <0.001). Pain after heating was observed a reduction in G2 (p <0.001). Among them there was a greater reduction (p <0.05) in G2. For pain was observed after walking a reduction in G1 (p <0.05) and G2 (p <0.001) before and after the protocols. Among them there was a reduction (p <0.05) higher in G2. In pain after exercise was observed a reduction in G2 (p <0.001). Among the groups there was a greater decrease in G2 (p <0.05). Conclusion: We conclude that the MEP ® helps reduce pain in functional activities. Keywords: Achilles tendon, tendinopathy, pain, physical therapy modalities, electrotherapy, analgesia, Electric Stimulation. ResumoIntrodução: As tendinopatias de calcâneo são a terceira lesão tendinosa mais frequente no sistema musculoesquelético. Novas alternativas terapêuticas têm sido propostas para o tratamento de tendinopatia como a Microelectrólisis Percutânea (MEP®). Objetivos:O objetivo desse estudo foi avaliar os efeitos da MEP® nas tendinopatias de calcâneo. Método: Trata-se de um ensaio clínico controlado, randomizado. A amostra foi composta por 20 pacientes que apresentavam tendinopatia de Aquiles. Os voluntários foram separados aleatoriamente em dois grupos, o controle (G1) submetido ao protocolo de tratamento convencional e o experimental (G2) à aplicação da MEP. Foram realizados dois atendimentos por semana durante um mês, totalizando oito atendimentos. Como método de avaliação foi utilizado 4 perguntas do questionário Visa-A relacionadas à funcionalidade e a prática de exercício. Os dados foram analisados através do teste t pareado e independente. Resultados: Na dor ao descer escadas foi observado uma redução no G1 (p<0,05) e G2 (p<0,001) antes e depois dos protocolos. Entre os grupos verificou-se uma redução maior no G2(p<0,001). Na dor após o aquecimento foi observado uma redução no G2 (p<0,001). Entre eles observou-se uma redução maior (p<0,05) no G2. Para a dor após caminhada foi verificada uma redução nos G1 (p<0,05) e G2 (p<0,001) antes...

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Experimental study of electrolysis-induced hepatic necrosis

Abstract: Predictable and reproducible areas of liver necrosis are produced with electrolysis. If these results extrapolate to larger animal models, this technique has potential for patients with irresectable primary and secondary liver tumours.

Cited by 51 publications

References 28 publications

Electrolytic Ablation of Colorectal Liver Metastases: 1-Year Histological Patient Follow-Up

Electrolytic Ablation of Colorectal Liver Metastases: 1-Year Histological Patient Follow-Up

Electrolytic Treatment of Colorectal Liver Tumour Deposits in a Rat Model: A Technique with Potential for Patients with Unresectable Liver Tumours

Effects of Microelectrólisis Percutaneous (MEP ®) on pain and functionality in patients with calcaneal tendinopathy.

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