Experimental study of devascularization of the colon.

Marston, Adrian; Marcuson, R. W.; Chapman, Malcolm; Arthur, J. F.

doi:10.1136/gut.10.2.121

Cited by 73 publications

(21 citation statements)

References 9 publications

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“…It can, however, become clinically evident after suppression of the inferior mesenteric arterial supply, for it can be observed after aortoiliac reconstructive surgery or left hemicolectomy for malignant lesions of the left colon . [7][8][9][10][11][12] In aortoiliac reconstructive surgery, intestinal ischemic complications can be found because the suppression of the inferior mesenteric artery system cannot be counterbalanced by an inadequate hypogastric system Such a situation becomes particularly severe when the superior mesenteric system is insufficient too. After left hemicolectomy, anastomosis leakage can sometimes be observed, even before the appearance of intestinal ischemic complication, due to an insufficient blood supply to the rectal stump, which, after suppression of the mesenteric arterial system, depends only on the hypogastric arterial system .…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Vascular Test with the 133Xe Clearance Technique in Assessment of Hypogastric Arteries Insufficiency

1986

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The 133 Xenon clearance technique is a valuable method of measuring blood flow in peripheral muscles. The purpose of this study was to evaluate this technique for measuring blood flow in the vascular bed of the hypogastric arteries.Clearance of 133 Xenon injected intravascularly in the gluteal region was studied in 10 healthy subjects and in 25 patients with aortoiliac disease to measure muscular blood flow (MBF) in this vascular bed. At rest, average MBF was higher in healthy subjects in both gluteal muscles than in the patients with arterial disease. After exercise-induced hyperemia, maximal MBF was markedly higher in healthy subjects than in the patients.The 133 Xe clearance is a simple and reliable procedure that could be especially useful for assessing the condition of the hypogastric arteries before surgical treatment of cancer in the left portion of the colon and in the rectum.

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Section: Discussionmentioning

confidence: 99%

Noninvasive Vascular Test with the 133Xe Clearance Technique in Assessment of Hypogastric Arteries Insufficiency

1986

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“…As with animals which had undergone arterial ligation (Marston et al, 1969), sigmoidoscopy proved to be a valuable method ofexamination of the venous lesions and revealed certain differences in the sequelae of the two operative procedures. Immediate postoperative examination demonstrated the considerably more rapid development of the venous lesion and the widespread blue congestion of the mucosa was quite different from the pale mucosal slough which characterized the severe arterial lesion.…”

Section: Discussionmentioning

confidence: 99%

“…The specimens were opened and washed clean with cold physiological saline, pinned out, and fixed in formalsaline in preparation for histological examination. RADIOLOGY Serial barium enemas were performed under general anaesthesia using the method described by Chapman in Marston et al (1969). Several dogs were examined on the first postoperative day.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Experimental venous lesions of the colon

Marcuson¹,

Stewart²,

Marston³

1972

Gut

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“…In 1969, Marston et al confirmed, in an experimental study on dogs, the relation between ischemia and the inflammatory reaction of the mucosa [2]. Since then, a number of morphological and functional studies on the vessels and microcirculation in chronic inflammatory bowel disease (IBD) have given rise to new hypotheses [survey in Refs.…”

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confidence: 96%

Endothelin-1 Receptor Antagonist (LU-135252) Improves the Microcirculation and Course of TNBS Colitis in Rats

et al. 2006

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The role of microcirculation in the pathogenesis and course of chronic inflammatory bowel disease is still unclear. The aim of this study was the evaluation of the role of microcirculation in colitis activity in the rat TNBS (trinitrobenzenesulfonic acid) colitis model using endothelin-1 and a selective endothelin-1 receptor antagonist (LU-135252). Target parameters were capillary blood flow, functional capillary density, vascular permeability, and leukocyte sticking as well as recording of hematocrit, weight course, diuresis, stool quality, and degree of inflammation using a histological colitis score. The acute phase of TNBS colitis is characterized by an extensive disturbance of microcirculation (a significant decrease in capillary blood flow and capillary density and a significant increase in capillary permeability and leukocyte sticking in the mucosa). There is also a significant increase in hematocrit and a significant decrease in diuresis and weight. An exogenous supply of endothelin-1 does not lead to an aggravation of these disorders because of a possible blockage of the endothelin-1 receptors by endogenous endothelin-1 in this florid inflammatory phase. Applying the selective endothelin-1 receptor A antagonist LU-135252 leads to a significant improvement of all microcirculatory parameters and clinical findings compared to the untreated colitis group. Direct improvement of capillary blood flow in the early phase of colitis leads to reduced colitis activity, which underscores the pathogenetic role of the microcirculation in the progression of colitis.

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Experimental study of devascularization of the colon.

Cited by 73 publications

References 9 publications

Noninvasive Vascular Test with the 133Xe Clearance Technique in Assessment of Hypogastric Arteries Insufficiency

Noninvasive Vascular Test with the 133Xe Clearance Technique in Assessment of Hypogastric Arteries Insufficiency

Experimental venous lesions of the colon

Endothelin-1 Receptor Antagonist (LU-135252) Improves the Microcirculation and Course of TNBS Colitis in Rats

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