Experimental Study of Combination of Extraaortic Balloon Counterpulsation and Ventricular Assist Cup to Acute Heart Failure in Dogs

Mitsumaru, Atsuhiro; Yozu, Ryohei; Inoue, Yoshito; Tanaka, Susumu; Yoshito, Hiroshi; Kanda, Katsuki; Tsutsui, Yoko; Tsutsui, Nobumasa; Kawada, Shiaki

doi:10.1097/00002480-199743030-00012

Cited by 3 publications

(3 citation statements)

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“…Several groups, however, have proposed the use of dynamic cardiac compression as a possible means to aid the failing heart and have tested these techniques in animals. 11,12 These studies suggest that external forces can be safely applied to the epicardial surface of the heart to improve contractile efficiency and cardiac output. Reports published by Anstadt et al 13,14 describe a method of direct mechanical ventricular actuation (DMVA) that involves placement of a contoured cup over both ventricles.…”

Section: Discussionmentioning

confidence: 99%

Copulsation Balloon for Right Ventricular Assistance

1999

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Background-Options for management of acute right ventricular (RV) failure are limited. This report describes preliminary testing of a temporary RV assist device that acts by direct compression of the RV. The system comprises a pancake-shaped silicone balloon (5 cm diameter) connected to a drive console that delivers a 65-mL pneumatic pulse during cardiac systole. Methods and Results-Initial in vivo tests were performed on 6 pigs (weight, 41Ϯ4 kg). RV wall motion and stroke volume were monitored via transesophageal echocardiography. Acute RV failure was created by graded right coronary ligation, which yielded a 63% reduction in RV stroke volume (39.9Ϯ8.2 to 14.7Ϯ1.9 mL; PϽ0.002). We secured the balloon over the RV free wall by attaching it to the edges of the opened pericardium. The sternum was then reapproximated, and data were collected with the device off and on (every beat). Device placement had no deleterious effect on RV function. Balloon activation returned RV stroke volumes to normal (37.8Ϯ9.2 mL) and increased mean pulmonary artery pressures from 13Ϯ2 to 16Ϯ3 mm Hg (PϽ0.01). RV compression did not induce or exacerbate tricuspid regurgitation. Mean aortic pressure improved from postinfarction levels but did not return to normal. Conclusions-We conclude that the pulmonary circulation can be supported in the short term via cardiac compression and that balloon copulsation techniques for short-term RV failure should be tested in long-term models. (Circulation. 1999;99:2815-2818.)

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Section: Discussionmentioning

confidence: 99%

Copulsation Balloon for Right Ventricular Assistance

1999

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“…After the basal state of rats was stable for 10 min, except for the NC group, the other groups were pumped with 0.4% propranolol solution (Sigma, USA) into the right femoral vein of rats at a constant rate (0.2 ml/min) of 4 mg/kg by a microinjection pump (Shanghai Orcott Biotechnology Co., Ltd.), and then the flow rate was adjusted to 0.25 mg/(kg·min) for continuous low-dose pumping until the end of hemodynamic testing. The LVSP, + dp/dtmax, and −dp/dtmax of the animals were significantly decreased, and a decrease of more than 40% in +dp/dtmax was used as the criterion for successful modeling of heart failure according to the literature [ 9 ]. The NC group was not modeled, and only the same dose of 0.9% NaCl was pumped as a control.…”

Section: Methodsmentioning

confidence: 99%

Synergistic and Attenuating Effect of Electroacupuncture on Aconitine in Improving Heart Failure and Its Calcium Regulation Mechanism

Zhou

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The objective is to observe the synergistic and attenuating effect of electroacupuncture (EA) on aconitine (ACO) in improving heart failure (HF) and to explore its underlying mechanism for calcium regulation. Methods. Twenty-four male Sprague-Dawley rats were randomly divided into four groups: normal control (NC) (n = 6), HF(n = 6), ACO (n = 6), and ACO + EA (n = 6). The maximum rates of left ventricular pressure rising and declining (±dp/dtmax), arrhythmia, the left ventricular systolic pressure (LVSP), ejection fraction (LVEF), and fractional shortening (LVFS) were measured by physiological recorder and ultrasound, respectively. Protein expressions of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2a), phospholamban (PLB), and Na+-Ca2+ exchange (NCX1) in the left ventricle tissue were detected by fluorescence immunoblotting. Results. Compared with the NC group, LVSP, ±dp/dtmax, LVEF, and LVFS were decreased in the HF group; compared with the HF group, LVSP, ±dp/dtmax, LVEF, and LVFS were significantly increased in the ACO + EA group. Compared with the ACO group, the incidence and the degree of arrhythmia were significantly reduced in the ACO + EA group. Compared with the NC group, the activity of SERCA2a was decreased, and the expression of PLB and NCX1 was enhanced in the HF group; compared with the HF group and ACO group, the activity of SERCA2a was increased, and the expression of PLB and NCX1 was significantly attenuated in the ACO + EA group. Conclusions. EA plays a synergistic and attenuated role in ACO improving HF, and the mechanism may be related to the enhancement of the SERCA2a activity and the decrease of the expression of PLB and NCX1 in cardiomyocytes.

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“…Therefore, an extra-aortic balloon pump (EABP) (Figure 8D) that wraps and compresses the external surface of the ascending aorta like the C-pulse device (Sunshine Heart Inc., Eden Prairie, MN) may offer clinicians an alternative solution. The C-pulse counterpulsation EABP was clinically tested and shown to significantly increase aortic peak diastolic pressure, cardiac output, and regional and coronary blood flow without touching the blood [103,116]. In the context of long-term cardiac support it is worth mentioning that, like the soft robotic DCCS, this device also has the potential to be driven by muscle-powered actuation, which would allow for durations of use far beyond what is now possible with pneumatic actuation.…”

Section: Innovations For Effective Long-term Cardiac Supportmentioning

confidence: 99%

Cardiac Assist Devices: Early Concepts, Current Technologies, and Future Innovations

Han

Trumble

2019

Bioengineering

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Congestive heart failure (CHF) is a debilitating condition that afflicts tens of millions of people worldwide and is responsible for more deaths each year than all cancers combined. Because donor hearts for transplantation are in short supply, a safe and durable means of mechanical circulatory support could extend the lives and reduce the suffering of millions. But while the profusion of blood pumps available to clinicians in 2019 tend to work extremely well in the short term (hours to weeks/months), every long-term cardiac assist device on the market today is limited by the same two problems: infections caused by percutaneous drivelines and thrombotic events associated with the use of blood-contacting surfaces. A fundamental change in device design is needed to address both these problems and ultimately make a device that can support the heart indefinitely. Toward that end, several groups are currently developing devices without blood-contacting surfaces and/or extracorporeal power sources with the aim of providing a safe, tether-free means to support the failing heart over extended periods of time.

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Experimental Study of Combination of Extraaortic Balloon Counterpulsation and Ventricular Assist Cup to Acute Heart Failure in Dogs

Cited by 3 publications

References 0 publications

Copulsation Balloon for Right Ventricular Assistance

Copulsation Balloon for Right Ventricular Assistance

Synergistic and Attenuating Effect of Electroacupuncture on Aconitine in Improving Heart Failure and Its Calcium Regulation Mechanism

Cardiac Assist Devices: Early Concepts, Current Technologies, and Future Innovations

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