Experimental study of bone tissue density in patients with congenital pseudarthrosis of the tibia bones before and after surgery according to computer tomography data

Abstract

Surgical treatment of congenital pseudarthrosis of the tibia bones is accompanied by a significant percentage of complications and refractions. One of the main reasons for the unsatisfactory results of treatment is the violation of the quality of bone tissue in the area of pseudoarthrosis, which is an obstacle to the normal process of fusion of the shin bones. Рurpose - use computed tomography to examine bone density in patients with congenital pseudoarthrosis of the tibia before and after surgery. Materials and methods. CT scans of the tibia of three patients with congenital pseudoarthrosis of the tibia, aged 5 to 7 years. The density in the Hounsfield units of the cortical layer above and below the nonunion zone was determined. Results. Prior to treatment, a significant decrease (p=0.001) in the density of the cortical layer of the tibia of the injured limb along its entire length was determined. One year after surgery, a statistically significant difference in the density of the cortical layer of the tibia remains. The optical density of the cortical layer of the damaged tibia is statistically significantly less than healthy (p=0.001). One year after surgical treatment by osteosynthesis with an intramedullary rod with axial mobility, the difference in the density of the cortical layer of the tibia of the healthy and operated limbs remains statistically significant (p=0.001) less than the bone density of the healthy limb. On the unoperated limb, a significant (p<0.05) increase in optical density of bones was observed in all studied areas. Conclusions. As a result of surgical treatment of congenital pseudoarthrosis of the tibia, there is a statistically significant increase in the density of the cortical layer. The density of the cortical layer of the bones of the operated shin a year after surgery is close to the density of the bones of a healthy limb. The increase in bone density of the operated limb is due not only to the growth of patients, but also occurs due to the possibility of loading the operated limb. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

Study of relative deformations of interfragmentary regenerate in models of different osteosynthesis options of tibia bones with fractures in the middle third in children with osteogenesis imperfecta and incomplete growth

“…10-вузловий тетраедр із квадратичною апроксимацією було обрано, як скінченний елемент. Під час обрання механічних властивостей біологічних тканин було враховано той факт, що при недосконалому остеогенезі кісткова тканина має низьку механічну міцність, на що було звернуто увагу під час вивчення літературних джерел [1,2,5,6,15]. Характеристики штучних матеріалів було обрано згідно із даними технічної літератури [11].…”