Experimental studies on the spread of cancer in the lymphatic system.II. Absence of a lymphatic supply in carcinoma

Zeidman, Irving; Copeland, Bradley E.; Warren, And Shields

doi:10.1002/1097-0142(1955)8:1<123::aid-cncr2820080116>3.0.co;2-a

Cited by 69 publications

(27 citation statements)

References 4 publications

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“…After the primary tumor has established itself in the mucosa, the first step in the mechanism of cancer metastasis is breach of the basement membrane [153,171]. The basement membrane is composed primarily of type IV collagen, which forms the structural scaffolding of the basement membrane, laminin, and proteoglycans.…”

Section: Discussionmentioning

confidence: 99%

“…Sometimes, lymph flow may completely bypass any intercurrent lymph node via pericapsular channels that have been demonstrated to connect the afferent and efferent lymphatics [171]. Processes like metastatic tumor cell infiltration and reactive lymph node hyperplasia that increase the hydrostatic pressure in the intervening lymph node have been shown to increase the flow through the path of least resistance at the pericapsular channels [119,146].…”

Section: 4mentioning

confidence: 99%

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A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: 4mentioning

confidence: 99%

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

et al. 2011

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“…We assume that bulk molecular transport is via diffusion. Neglecting the influence of convection on tracer delivery can be justified by the many observations of low convection within tumours, due to the absence of functioning lymphatics (Padera et al, 2002;Zeidman et al, 1955) and the higher permeability of tumour blood vessels (Baxter and Jain, 1991). We further assume that reactions follow Michaelis-Menten-type kinetics; i.e.…”

Section: Model Developmentmentioning

confidence: 99%

Tumour glycolysis: The many faces of HIF

Kelly

Smallbone

Brady

2008

Journal of Theoretical Biology

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a b s t r a c tWe present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the hypoxic microenvironment and intracellular signalling on the glycolytic response of tumour tissue, finding that the glycolytic state is dependent on a delicately balanced interplay between the cellular hypoxic response, mediated by hypoxia-inducible factor-1a (HIF-1a), and growth-factor signalling cascades, which are frequently mutated in cancers. Our findings demonstrate the importance of considering both environmental and intracellular regulation when interpreting tumour metabolism for diagnostic or prognostic purposes. To illustrate this, we demonstrate the potential impact of this multi-factorial regulation on the kinetics of radiolabelled glucose analogues, used in positron emission tomography (PET).

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“…However, in this series, it was found that, allowance being made for elution of isotope, the majority of tumour cells immediately retained by the node remained so for a 24-hour period. A previous series of experiments showed that the regional lymph node would act as a temporary barrier to the further spread of tumour growth; this was established by Zeidman, Copeland and Warren (1954), with a similar animal model, who showed that excision of the lymph node up to 3 weeks after injection of the Vx2 cell suspension, eliminated the tumour. It seems probable, therefore, that those cells which transgress the lymph node are less able to produce metastases than those trapped by it.…”

Section: Experimental Techniquementioning

confidence: 91%

The effect of cortisone therapy and limb exercise on the retention of tumour cells by the regional lymph node.

Stoker¹

1969

Br J Cancer

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EXPERIMENTS have shown that cortisone therapy and limb exercise botlh enhance the dissemination of the Vx2 carcinoma via the lymphatic system of the rabbit (Stoker, 1969). Further investigations have been carried out to determine the degree of retention of tumour cells by the normal lymph node and the effect of these two factors on it.Gray and Sterling (1950) developed a method for labelling red blood cells with radio-active sodium chromate, which has been modified by Rajam, Jackson and Black (1958) and by Selecki (1959) for use with tumour cell suspensions. Fisher and Fisher (1967) reported the use of labelled Vx2 tumour cells to determine their retention by the popliteal lymph node of the rabbit. They found that, using a wide range of tumour cell inoculation size, the regional lymph node was a very inefficient barrier to the further spread of tumour cells; the majority of tumour cells transgressed the lymph node and most of them were deduced to have left it by way of the venous system. These findings are difficult to reconcile with previous experimental findings that the regional lymph node will temporarily limit tumour growth. MATERIALS AND METHODS An M1leasurements of radio-activityThese were made in a sodium iodide scintillation well counter of 5 ml. capacity, comparing equal volumes of specimens; 5'Cr is an emitter of y-irradiation and has a half life of 27-8 days.

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Experimental studies on the spread of cancer in the lymphatic system.II. Absence of a lymphatic supply in carcinoma

Cited by 69 publications

References 4 publications

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

Tumour glycolysis: The many faces of HIF

The effect of cortisone therapy and limb exercise on the retention of tumour cells by the regional lymph node.

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