Experimental Studies on the Effect of Chlorpyriphos and Lead Acetate on Biochemical Parameters in Wistar Rats with Special Reference to Ameliorative Effect of Vitamin C

Nisar, Nisar Ahmad; Sultana, Mudasir; Raina, Rajinder; Waiz, Hina Ashraf; Baba, Naseer Ahmad; Ahmad, Irshad; Zargar, Fayaz Ahmad

doi:10.1007/s40011-013-0237-z

Cited by 1 publication

(1 citation statement)

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“…The exposure indicates reduced glomerular function (Ali and Ismail, 2012), because these metabolic parameters are the waste products of protein metabolism requiring excretion through the kidney (Al-Attar and Al-Tisan, 2010). These findings corroborated with previous investigations in pregnancy rats (Zama et al, 2005), lactating rats (Mansour and Mossa, 2011) and in adult male and female rats (Mansour and Mossa, 2010;Nisar et al, 2013) treated by CPF. The analysis of blood yields information about the predominant metabolic pathways in the body.…”

Section: Discussionsupporting

confidence: 93%

Effects of exposure of chlorpyrifos-ethyl on metabolism and oxidative damage in rats and their offspring

Khawla ABDERRAHIM,

Meryem BENSALAH,

Samira BOUANANE

et al. 2022

jnpra

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Chlorpyrifos-ethyl (CE) is one of the most widely used organophosphorus insecticides for industrial, agricultural and public health purposes. The aim of the study was to evaluate the effect of CE exposure via gavage on metabolic and redox status in pregnant, lactating rats and their pups at weaning. The oral administration of this pesticide at doses of 1 mg/kg of body weight No Observed Adverse Effects Level (NOAEL), 5.4mg/kg b.wt (1/25LD50) and 13.5 mg/kg b.wt (1/10LD50) was given 1day/2 to female rats during the entire gestation and lactation period. Plasma biochemical parameters as well as lipid profiles and oxidative stress markers were determined. Oral CE exposure induced an increase in plasma glucose, urea, creatinine and lipid status levels in mothers at parturition (day 0) and at the end of lactation (day21) and in their offspring at weaning (day21). An altered oxidant/antioxidant status marked in mothers treated by the insecticide at day 0 and day 21 and these disturbances were also seen in their offspring. In conclusion, different doses CE exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to offspring metabolic changes. CE should be used with caution especially during pregnancy and lactation period.

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Section: Discussionsupporting

confidence: 93%