Experimental studies on the chronic toluene poisoning. : Findings on the peripheral blood and the suprarenal glands

Takeuchi, Yu; Matsusita, T.; Takeuchi, S

doi:10.1539/joh1959.10.4_214_2

Cited by 2 publications

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“…A similar, although blunted pattern was observed for the highest doses of toluene during the first week (Hsieh et al 1991). Finally, evidence of the capability of toluene to suppress the hypothalamic‐pituitary‐adrenal‐axis comes from observation of decreased relative adrenal weight and thinning of the Zona faciculata after 32 weeks of exposure to 200–1000 ppm toluene, 8 hr/day (Takeuchi 1969). In the present study pregnant rats were exposed to 1500 ppm toluene and exhibited lowered plasma levels of corticosterone, when measured 8 and 12 days into exposure.…”

Section: Resultsmentioning

confidence: 99%

Toluene Depresses Plasma Corticosterone in Pregnant Rats

Hougaard

Hansen

Hass

et al. 2003

Pharmacology & Toxicology

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Combined exposure to stressors and chemicals may result in synergistic effects. The effects of prenatal exposure to the organic solvent toluene resemble those observed in offspring of gestationally stressed dams, a possible common mechanism being transfer of stress-/toluene-induced increments of corticosteroids from the maternal to the foetal compartment. Pregnant rats were subjected to either 1500 ppm toluene 6 hr/day and/or a schedule of ''Chronic mild stress'' during the last two weeks of gestation. Exposure to toluene was associated with reduced birth weight and lower maternal weight gain, the latter being enhanced by maternal stress. A depressant effect of toluene on maternal corticosterone was observed, hence the study does not provide immediate evidence that transfer of elevated levels of corticosterone from the maternal to the foetal compartment mediates the effects of prenatal exposure to toluene.

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Section: Resultsmentioning

confidence: 99%

Toluene Depresses Plasma Corticosterone in Pregnant Rats

Hougaard

Hansen

Hass

et al. 2003

Pharmacology & Toxicology

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“…63 1930-1940's) at times contained as much as 15% benzene. More recent studies, with analytically pure toluene containing almost no benzene, indicate that toluene alone does not cause blood or bone marrow disorders (Takeuchi, 1969;Gerarde, 1956;Speck and Moeschlin, 1968). It is important to point out that benzene can still be an impurity in toluene used today and therefore, it is important to thoroughly analyze the toluene sample to insure the absence of impurities prior to conducting toxicological studies.…”

Section: Toxicologymentioning

confidence: 99%

Health Effects of the Alkylbenzenes. I. Toluene

1988

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The alkylbenzenes, toluene being the most common example, represent a class of six-membered ring aromatic compounds that have a variety of alkyl groups attached. These chemicals are liquids with relatively low boiling points and are used primarily as solvents or as starting materials in the synthesis of other chemicals and drugs. They are also integral components of gasoline, distillate fuels and other petroleum products. These substituted aromatics are economically important in the chemical, petroleum, pharmaceutical, polymer, paint and dye industries. Alkylbenzenes such as toluene, xylene, ethylbenzene, styrene and cumene are toxicologically important since they are produced, used or disposed of in the largest quantities and therefore might pose significant and potential health risks to man and the environment. In general, the toxicity of alkylbenzenes has been found to be relatively low. Also, for the most part, human and environmental risks are low; however, there may be a few operations where the potential for high exposure could exist. These exposures are minimized by workplace controls or personal protective equipment. Furthermore, health risks for humans are minimized by guidelines for maximum allowable exposure concentrations which have been established for the workplace. This present paper reviews the toxicology and disposition of toluene in animals and humans.

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Experimental studies on the chronic toluene poisoning. : Findings on the peripheral blood and the suprarenal glands

Cited by 2 publications

References 0 publications

Toluene Depresses Plasma Corticosterone in Pregnant Rats

Toluene Depresses Plasma Corticosterone in Pregnant Rats

Health Effects of the Alkylbenzenes. I. Toluene

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