Experimental studies on 3D printing of barium titanate ceramics for medical applications

Schult, Mark; Buckow, Eric; Seitz, Hermann

doi:10.1515/cdbme-2016-0024

Cited by 23 publications

(19 citation statements)

References 13 publications

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“…After sintering, the largest contraction was observed in the case of the M1 sample, of 75.53%, but the other two also recorded relatively high contractions, M2 of 40.55% and M3 of 29.51%. The results reported in their study confirm that porous barium titanate ceramics can be used as a 3D structure for bone tissue engineering and bone formation can be promoted by electrical stimulation [25].…”

Section: Introductionsupporting

confidence: 54%

“…Regarding 3D printing of barium titanate (BT) ceramics for medical applications, Schult et al [25], have shown that BT powder can serve as a material for bone reconstruction, obtained by 3D printing cylindrical parts with 11.7 mm in diameter and 3.51 mm high, out of the three BT-based mixtures. The first mixture, M1, consisted of untreated BT powder, a stable polymer, and a flow additive-AEROSIL R8200.…”

Section: Introductionmentioning

confidence: 99%

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Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Piticescu¹,

Cursaru²,

Negroiu³

et al. 2020

Biomaterials

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Barium titanate (BT) and barium strontium titanate (BST) are one of the most studied ferroelectric materials with excellent piezoelectric properties, which can be used to stimulate bone formation by applying an electrical field. It is known that this ceramic is biocompatible and can be used for medical applications. New hybrid materials based on BT and collagen and BST and collagen, with potential applications in bone reconstruction, are presented, emphasizing the potential of fabricating 3D structures by integrating hydrothermal synthesis with additive manufacturing. Designing such structures may take advantage of rheological characterization at single-molecule level for some elastic biopolymers like titin and collagen and their molecular dissection into structural motifs that independently contribute to the protein viscoelasticity. Atomic force spectroscopy measurements on synthetic polypeptides showed that a polypeptide chain containing Ig domain modules is protected against rupture at high stretch by Ig domain unfolding, an important mechanism for stress relaxation in titin molecules. This property may be exploited to enhance the tensile strength of a 3D structure by adding specific synthetic polypeptides to the composition of the printing paste.

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Section: Introductionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Piticescu¹,

Cursaru²,

Negroiu³

et al. 2020

Biomaterials

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show abstract

“…3D printed BT [237][238][239], modified KNN [240], PVDF [241,242] and PLLA [243] have recently been fabricated for piezoelectric sensors and functional scaffolds which have limitedly been researched for tissue engineering applications. There are however challenges in processing and formulation of the raw material for printing and inducing piezoelectricity.…”

Section: D Printing Of Piezoelectric Materialsmentioning

confidence: 99%

“…printed cylindrical green parts (11.7 mm diameter and 3.51 mm height) for making BT scaffolds [238]. It was observed that the green bodies formed were unstable and sintering lead to substantial shrinkage.…”

Section: D Printing Of Piezoelectric Materialsmentioning

confidence: 99%

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

2018

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Electrical stimulation/electrical microenvironment are known effect the process of bone regeneration by altering the cellular response and are crucial in maintaining tissue functionality. Piezoelectric materials, owing to their capability of generating charges/potentials in response to mechanical deformations, have displayed great potential for fabricating smart stimulatory scaffolds for bone tissue engineering. The growing interest of the scientific community and compelling results of the published research articles has been the motivation of this review article. This article summarizes the significant progress in the field with a focus on the fabrication aspects of piezoelectric materials. The review of both material and cellular aspects on this topic ensures that this paper appeals to both material scientists and tissue engineers.

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“…In the following study, a composition containing 68 wt.% BaTiO 3 , 18 wt.% HA and 14 wt.% PEMA, featuring high flowability crucial for powder-based printing was used [23]. The resulting material mixture will be called BaTiO 3 /HA composite.…”

Section: Fabricationmentioning

confidence: 99%

3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering

et al. 2020

Self Cite

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The prevalence of large bone defects is still a major problem in surgical clinics. It is, thus, not a surprise that bone-related research, especially in the field of bone tissue engineering, is a major issue in medical research. Researchers worldwide are searching for the missing link in engineering bone graft materials that mimic bones, and foster osteogenesis and bone remodeling. One approach is the combination of additive manufacturing technology with smart and additionally electrically active biomaterials. In this study, we performed a three-dimensional (3D) printing process to fabricate piezoelectric, porous barium titanate (BaTiO3) and hydroxyapatite (HA) composite scaffolds. The printed scaffolds indicate good cytocompatibility and cell attachment as well as bone mimicking piezoelectric properties with a piezoelectric constant of 3 pC/N. This work represents a promising first approach to creating an implant material with improved bone regenerating potential, in combination with an interconnected porous network and a microporosity, known to enhance bone growth and vascularization.

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Experimental studies on 3D printing of barium titanate ceramics for medical applications

Cited by 23 publications

References 13 publications

Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering

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