Experimental Studies of Factors Causing Blood-Borne Dissemination in Cancer of the Colon and Rectum [<i>Abridged</i>]

McKinna, J A; Rowbotham, H D

doi:10.1177/003591577106400542

Cited by 5 publications

(1 citation statement)

References 4 publications

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“…Fibrinolytic agents liberate malignant cells from resected tumors, which suggests that natural fibrinolysis plays a role in tumor cell shedding. 106…”

Section: Possible Roles Of Peritumor Fibrin Tumor Cell Sheddingmentioning

confidence: 99%

Hemostasis and Malignancy

Francis¹,

Biggerstaff²,

Amirkhosravi³

1998

Semin Thromb Hemost

123

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There is considerable evidence that the hemostatic system is involved in the growth and spread of malignant disease. There is an increased incidence of thromboembolic disease in patients with cancers and hemostatic abnormalities are extremely common in such patients. Antihemostatic agents have been successfully used to treat a variety of experimental tumors, and several clinical trials in humans have been initiated. Although metastasis is undoubtedly multifactorial, intravascular coagulation activation and peritumor fibrin deposition seem to be important. The mechanisms by which hemostatic activation facilitates the malignant process remain to be completely elucidated. Of central importance may be the presence on malignant cells of tissue factor and urokinase receptor. Recent studies have suggested that these proteins, and others, may be involved at several stages of metastasis, including the key event of neovascularization. Tissue factor, the principal initiator of coagulation, may have additional roles, outside of fibrin formation, that are central to the biology of some solid tumors.

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“…Fibrinolytic agents liberate malignant cells from resected tumors, which suggests that natural fibrinolysis plays a role in tumor cell shedding. 106…”

Section: Possible Roles Of Peritumor Fibrin Tumor Cell Sheddingmentioning

confidence: 99%

Hemostasis and Malignancy

Francis¹,

Biggerstaff²,

Amirkhosravi³

1998

Semin Thromb Hemost

123

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Carcinoma of the colon and rectum: Circulating malignant cells and five-year survival

Griffiths

McKinna

Rowbotham

et al. 1973

Cancer

109

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Circulating malignant cells are found infrequently in the peripheral blood of patients with carcinoma of the colon and rectum. The incidence rises on induction of anesthesia (28%), and tumor cells can be identified in the peripheral blood of 50% of patients during surgery. Some of the important features in their cytologic identification (and distinction from other large mononu‐clear cells) are reported. There is a 57% yield when the blood sample is taken from the inferior mesenteric vein draining the tumor in the rectum or left colon. Five‐year follow‐up on two series of 50 patients shows that the detection of circulating malignant cells has no prognostic significance, and it is not related to the presence of histologic evidence of venous invasion, although this invasion itself is associated with a worse outlook. Fifty‐six per cent of patients in whom circulating tumor cells were found at surgery are alive and well without sign of recurrence or metastasis. In cases where blood samples were taken from the common or internal iliac vein before and after ligation of the inferior mesenteric vein, it was noted that patients with no detectable circulating tumor cells had a tendency towards liver metastases, whereas those showing circulating cells in pelvic veins, only after mesenteric vein ligation, had a tendency towards systemic bony deposits. During the isolated perfusion of excised tumors, it was found that addition of a fibrinolytic agent caused the liberation of large numbers of cells. Naturally occurring fibrinolysis may play a part in the liberation of cells into the bloodstream and in their subsequent ability to establish metastases.

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Review of literature on diseases of the colon and rectum

Rowe

Reinmiller

1973

Diseases of the Colon &Amp; Rectum

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Experimental Studies of Factors Causing Blood-Borne Dissemination in Cancer of the Colon and Rectum [Abridged]

Cited by 5 publications

References 4 publications

Hemostasis and Malignancy

Hemostasis and Malignancy

Carcinoma of the colon and rectum: Circulating malignant cells and five-year survival

Review of literature on diseases of the colon and rectum

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