Experimental Streptococcal Infection in the Rhesus Monkey*

Vanace, Peter W.

doi:10.1111/j.1749-6632.1960.tb50011.x

Cited by 9 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Myocardial and endothelial damage due to infiltration of granulocytes, macrophage and lymphocytes were observed in New Zealand White Rabbits injected with GAS M proteins ( 28 , 29 , 37 ) ( Table 1 ). In addition, GAS pharyngeal spray on non-human primate (rhesus monkey, Macaca mulatta ) induced typical RHD lesions as well as evidence of myocarditis and valvulitis along with infiltration of lymphocytes, histiocytes, Anitshkow cells, and plasma cells ( 38 ). Later, subcutaneous injection of GAS membrane antigens to rhesus monkeys' showed similar histological changes with endocardial and sub endocardial infiltration of mononuclear cells ( 39 ).…”

Section: Animal Models Of Arf/rhdmentioning

confidence: 99%

Requirements for a Robust Animal Model to Investigate the Disease Mechanism of Autoimmune Complications Associated With ARF/RHD

Rafeek

Sikder

Hamlin

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

The pathogenesis of Acute Rheumatic Fever/Rheumatic Heart Disease (ARF/RHD) and associated neurobehavioral complications including Sydenham's chorea (SC) is complex. Disease complications triggered by Group A streptococcal (GAS) infection are confined to human and determining the early events leading to pathology requires a robust animal model that reflects the hallmark features of the disease. However, modeling these conditions in a laboratory animal, of a uniquely human disease is challenging. Animal models including cattle, sheep, pig, dog, cat, guinea pigs rats and mice have been used extensively to dissect molecular mechanisms of the autoimmune inflammatory responses in ARF/RHD. Despite the characteristic limitations of some animal models, several rodent models have significantly contributed to better understanding of the fundamental mechanisms underpinning features of ARF/RHD. In the Lewis rat autoimmune valvulitis model the development of myocarditis and valvulitis with the infiltration of mononuclear cells along with generation of antibodies that cross-react with cardiac tissue proteins following exposure to GAS antigens were found to be similar to ARF/RHD. We have recently shown that Lewis rats injected with recombinant GAS antigens simultaneously developed cardiac and neurobehavioral changes. Since ARF/RHD is multifactorial in origin, an animal model which exhibit the characteristics of several of the cardinal diagnostic criteria observed in ARF/RHD, would be advantageous to determine the early immune responses to facilitate biomarker discovery as well as provide a suitable model to evaluate treatment options, safety and efficacy of vaccine candidates. This review focuses on some of the common small animals and their advantages and limitations.

show abstract

Section: Animal Models Of Arf/rhdmentioning

confidence: 99%