Experimental social rejection increases dyspnoea perception and neural processing of respiratory sensations in healthy subjects

Herzog, Michaela; Sucec, Josef; Vuković, Milica; Diest, Ilse Van; Bergh, Omer Van den; Leupoldt, Andreas von

doi:10.1183/13993003.01409-2018

Cited by 9 publications

(9 citation statements)

References 17 publications

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“…The successful dyspnea induction was further supported by respiratory variables demonstrating lower f and V' as well as higher TI and PImax during the dyspnea compared to the baseline condition. These respiratory related findings are in line with previous research using similar dyspnea induction methods (Alexander-Miller & Davenport, 2010;Alius, Pané-Farré, Von Leupoldt, & Hamm, 2013;Herzog, Sucec, Vukovic, et al, 2019;Peiffer, Costes, Hervé, & Garcia-Larrea, 2008). A small, but statistically significant difference for ETCO2 was found, which was within the normal range and, thus, presumably had no effect on the outcome measures (Bloch-Salisbury, Lansing, & Shea, 2000) Confirming our hypothesis, dyspnea affected the ERPs related to recognition memory.…”

Section: Discussionsupporting

confidence: 90%

The effect of dyspnea on recognition memory

Sucec

Herzog

Bergh

et al. 2020

International Journal of Psychophysiology

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Dyspnea is a debilitating symptom in various prevalent diseases. Previous research demonstrated several cognitive impairments in dyspneic patients including an impairment in recognition memory. Even though some factors contributing to these impairments have already been identified (e.g., smoking, medication), the relevance of dyspnea as one of those contributing factors is still unclear. Thus, the goal of the current study was to investigate whether acute dyspnea impairs recognition memory in a picture recognition task as indexed by reduced accuracy and a reduced old-new effect in event-related potentials (ERPs) in the electroencephalogram (EEG). Fifty healthy participants underwent a passive encoding phase without dyspnea induction, followed by the picture recognition task performed during an unloaded baseline and a resistive load induced dyspnea condition while EEG was continuously measured. Results indicated comparable accuracy during the baseline and dyspnea condition. A reduced fronto-central old-new effect during dyspnea compared to baseline was found for ERPs in the latency ranges 350-500, 500-800, 800-1100, and 1110-1400 ms. These findings suggest that dyspnea influences the process of familiarity (350-500 ms) and recollection (500-800 ms) as well as post-retrieval processes (800-1100 and 1100-1400 ms), highlighting a potential impairing effect of acute dyspnea on recognition memory.

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Section: Discussionsupporting

confidence: 90%

The effect of dyspnea on recognition memory

Sucec

Herzog

Bergh

et al. 2020

International Journal of Psychophysiology

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“…Prior to the experimental phase on T1 and T5, maximal inspiratory pressure (MIP) was measured with a handheld electronic device (POWERbreathe, HaB International Ltd, Southam, United Kingdom) to control for possible training effects with higher MIP values indicating greater muscular strength and capacity of the respiratory apparatus (Wijkstra et al, 1994). Furthermore, participants underwent a load magnitude estimation task (Herzog et al, 2018c, 2019; Sucec et al, 2018a) on T1 to pre-determine the individual inspiratory resistive load level that corresponds best with a dyspnea intensity rating of “strong” being represented by a “5” on a modified Borg scale (range: 0–10; Borg, 1990). This magnitude of dyspnea was used to induce strong dyspnea on all testing days.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Repeated Dyspnea Exposure on Response Inhibition

et al. 2019

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In order to treat dyspnea (=breathlessness) successfully, response inhibition (RI) as a major form of self-regulation is a premise. This is supported by research showing that self-regulation is associated with beneficial behavioral changes supporting treatment success in patients. Recent research showed that dyspnea has an impairing effect on RI, but the effects of repeated dyspnea exposure on RI remain unknown. Therefore, the present study tested the effects of repeated resistive load-induced dyspnea on RI over a 5-day period. Healthy volunteers ( n = 34) performed the standard version of the Stroop task during baseline and dyspnea conditions on the first and fifth testing day and underwent an additional dyspnea exposure phase on each testing day. Variables of interest to investigate RI were reaction time, accuracy as well as the event-related potentials late positive complex (LPC) and N400 in the electroencephalogram. Reduced accuracy for incongruent compared to congruent stimuli during the dyspnea condition on the first testing day were found ( p < 0.001). This was paralleled by a reduced LPC and an increased N400 for incongruent stimuli during the induction of dyspnea ( p < 0.05). After undergoing dyspnea exposure, habituation of dyspnea intensity was evident. Importantly, on the fifth testing day, no differences between baseline, and dyspnea conditions were found for behavioral and electrophysiological measures of RI. These findings demonstrate that the impairing effect of dyspnea on RI disappeared after repeated dyspnea exposure in healthy participants. Translated to a clinical sample, it might cautiously be suggested that dyspnea exposure such as dyspnea perceived during physical exercise could reduce the impairing effect of dyspnea on RI which might have the potential to help increase self-regulation abilities and subsequent treatment efforts in dyspneic patients.

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“…The rejection condition was set up through a virtual balltossing game, and participants were randomly assigned to either experiencing social rejection or not. Higher perception of dyspnea was shown in the presence of social rejection [22]. No effect size measures were reported within the studies.…”

Section: Experienced Breathlessnessmentioning

confidence: 81%

“…Experienced breathlessness was associated with both psychological factors, such as social rejection [22], presence of others [21 && ], low level of function [26], prenatal exposure to stress [23], and physiological factors, such as hyperventilation [19], hypoxia [26], the presence of pulmonary, lymph node [odds ratio (OR) 1.79; 95% confidence interval (CI) ], walking speed [18], and reduced neural gating [20].…”

Section: Experienced Breathlessnessmentioning

confidence: 99%

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Differences between experienced and recalled breathlessness: a review

Sandberg

Ekström²

2019

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of reviewExperienced breathlessness and recalled breathlessness are two different entities, which may be associated with different factors and might have different impacts on function for the individual. The aim was to review the knowledge from the last 2 years concerning experienced breathlessness and recalled breathlessness and related factors. Recent findingsExperienced breathlessness was most often induced or measured during exercise testing in a lab environment using a modified Borg scale. It was associated with both psychological factors, such as social rejection, presence of others, psychosocial stress and prenatal exposure to stress, as well as physical factors, such as hypoxia and frequent exacerbations. Recalled breathlessness was most often measured in epidemiological studies, most commonly using the modified Medical Research Council scale. It was associated with lung volumes, overweight, exercise training, frailty, smoking, personality traits, behavior and marital and occupational status. SummaryNo studies during the review period had directly compared experienced breathlessness and recalled breathlessness. Several factors were related to either experienced breathlessness or recalled breathlessness but no clear differences between factors were found in this review. There is a need for comparative studies using the same measurement methods and in the same settings in order to examine their relation.

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Experimental social rejection increases dyspnoea perception and neural processing of respiratory sensations in healthy subjects

Cited by 9 publications

References 17 publications

The effect of dyspnea on recognition memory

The effect of dyspnea on recognition memory

The Effects of Repeated Dyspnea Exposure on Response Inhibition

Differences between experienced and recalled breathlessness: a review

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