Experimental sleep fragmentation in normal subjects

Stepanski, Edward J.; Lamphere, James; Roehrs, Timothy; Zorick, Frank; Roth, Thomas

doi:10.3109/00207458708987405

Cited by 109 publications

(80 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…amount of stage 1 and SWS, with an additional influence of indices of daytime sleepiness and BMI. On the basis of these results, it is difficult to discriminate fully between the effects of breathing disorders on sleep structure and the effects of diurnal sleepiness, as the two factors may be interrelated [26]. However, assuming that the amount of SWS and stage 1 are indicative of sleep continuity and sleep restorative ability [27], the sleepdisturbing effects of the respiratory events accumulated during one night9s sleep may lead to tiredness and fatigue [28], which may be reflected by a decrease in physical function.…”

Section: Discussionmentioning

confidence: 99%

Determinants of altered quality of life in patients with sleep-related breathing disorders

Sforza¹,

Janssens²,

Rochat³

et al. 2003

Eur Respir J

View full text Add to dashboard Cite

Determinants of altered quality of life in patients with sleep-related breathing disorders. E. Sforza, J.P. Janssens, T. Rochat, V. Ibanez. #ERS Journals Ltd 2003. ABSTRACT: Recent reports have suggested that altered quality of life and well-being are reported by patients with sleep-related breathing disorders (SRBD). There seems to be no data available in the literature on factors underlying these behavioural consequences. In this study, health-related quality of life (HRQL) scores were examined in SRBD patients in order to establish which factors are implicated in these disturbances.The study group consisted of 130 patients: 49 snorers and 81 patients with obstructive sleep apnoea. The Medical Outcome Survey Short Form-36 questionnaire was administered the morning after the sleep study and scores for the eight dimension scores were obtained. Patient9s data were compared to normative sex-and age-matched data.In comparison with normal values, scores for all HRQL dimensions were decreased in SRBD patients, with a greater impact on subscores for "vitality", "physical role", "social functioning", "mental health" and "role emotional" dimensions. While impairment in physical function was mostly influenced by sleep stage and obesity, subjective daytime sleepiness mainly affected the other dimensions.The authors conclude that the altered health-related quality of life of sleep-related breathing disorder patients is a multifactorial phenomenon depending on the interaction of sleep stages, daytime sleepiness and obesity, with no significant contribution of sleep fragmentation, hypoxaemia and apnoea recurrence. Sleep-related breathing disorders (SRBD) are common disorders, which affect o2-4% of the general population and are characterised by repetitive pharyngeal collapse during sleep, inducing sleep fragmentation and nocturnal hypoxaemia. These two factors have been suggested as causal factors of the excessive daytime sleepiness and neuropsychological and cognitive disturbances affecting the daytime functioning of these patients. Several studies have demonstrated that a large number of patients with SRBD may also have altered health-related quality of life (HRQL) scores, using either generic questionnaires, such as the Nottingham Health Profile [1,2] or the Medical Outcome Survey Short Form (SF)-36 [3], or disease-specific questionnaires, such as the Calgary Sleep Apnea Quality of Life [4,5]. These all showed impairment more frequently in vitality and social functioning [6]. Despite the frequent association between SRBD and altered daily functioning and well-being [7,8], and the importance of altered quality of life in SRBD [6], no data are available in the literature concerning the mechanisms underlying these psychological disturbances. This could be due, at least in part, to the fact that quality of life scores are not routinely used by clinicians to detect the impact of the sleep disorder on the well-being of their patients [9] and also to the difficulty in defining which parameters better reflect a clinically meaning...

show abstract

Section: Discussionmentioning

confidence: 99%

Determinants of altered quality of life in patients with sleep-related breathing disorders

Sforza¹,

Janssens²,

Rochat³

et al. 2003

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…Experimentally induced arousals at a rate of 20 events per hour causes impaired daytime alertness in adults. 27 It is difficult to evaluate daytime sleepiness in these children, since they are often mistakenly diagnosed with learning disabilities or behavioral disorders. 19 The clinical signs of sleepiness, such as yawning, impaired concentration, deficits in the performance of vigilance tasks, or irritability, are similar to those of learning disabilities or behavior disorders.…”

Section: Commentmentioning

confidence: 99%

Sleep Fragmentation in Children With Atopic Dermatitis

Reuveni¹,

Chapnick²,

Tal³

et al. 1999

Arch Pediatr Adolesc Med

102

View full text Add to dashboard Cite

To characterize the sleep pattern of children with atopic dermatitis in clinical remission.Methods: Fourteen children with atopic dermatitis, with a mean ± SD age of 6 ± 2 years, were recruited consecutively from a pediatric dermatology clinic. No participant had any other medical or psychiatric illness. The control group (n = 9, mean age 7 ± 1.8 years) was composed of children with mild "benign" snoring and no evidence of respiratory disturbance during sleep. All participating children were evaluated by formal all-night polysomnography, scratch electrodes, and self-reported questionnaires filled in by their parents.Results: The patients were studied when their skin condition was in remission. Sleep latency, total sleep time, and sleep efficiency were similar to the control group. The atopic dermatitis group had an average of 24.1 ± 8.1 events per hour of arousals and awakenings, compared with 15.4 ± 6.2 events per hour in the control group (PϽ.001). Direct observation, video monitoring, and scratch electrodes provided evidence of between 1 to 19 bouts of scratching per night, accounting for only 15% of the arousals and awakenings. The rest of the arousals and awakenings were not associated with any specific, identifiable polysomnographic event, such as apnea or jerks. Conclusion:Children with atopic dermatitis in clinical remission have sleep disturbances that are not related to scratching per se.

show abstract

“…Disrupted sleep further increases negative mood characteristics [10]. Sleep problems might be underestimated due to accumulation of a symptom burden with overlapping and co-existing disease related symptoms.…”

Section: Introductionmentioning

confidence: 99%

Fragmented sleep: An unrevealed problem in peritoneal dialysis patients

Yngman-Uhlin

Johansson

Fernström

et al. 2011

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

Objective: The aim of this study was to describe the sleep-wake cycle, sleep quality, fatigue and HRQoL measured with questionnaires, actigraphy and sleep a diary during a one-week period in patients with peritoneal dialysis treatment at home. Further, to explore differences compared to patients with coronary artery disease (CAD) and individuals from the general population. Material and Methods:In this study one week, actigraphy registration, four questionnaires (Uppsala Sleep Inventory, SF-36, FACIT-fatigue, International Restless Legs Study Groups´ form) and a sleep diary were used. Results:In total data from 68 participants and 470 nights were collected. PD-patients (n=28) had more fragmented sleep (p<0.001) and worse sleep efficiency (SE) (p<0.0001) compared to the CAD (n=22) and the population (n=18) groups. Pruritus (57%), restless legs (46%) and fatigue (89%) were prevalent in PD-patients. Pruritus correlated to fragmented sleep (r=-0.45, p=0.01) and SE (r=-0.49, p =0.01). In HRQoL, the physical component score was decreased in the PD and angina groups (p<0.01) compared to the population group.Conclusions: To our knowledge this study is the first to demonstrate that PD-patients have a deteriorated sleep with serious fragmentation measured with a one-week actigraphy registration. Further, PD-patients exhibit worse sleep quality compared to CAD patients and individuals in the population. More evaluation of sleep in clinical practice is highly recommended since PD-patients are vulnerable individuals with extended self-care responsibilities and at risk for co-morbidity secondary to insufficient. Future research on whether PD-patient´ sleep problems and fatigue can be improved by an individual nonpharmacological intervention programme is required.3

show abstract

Experimental sleep fragmentation in normal subjects

Cited by 109 publications

References 5 publications

Determinants of altered quality of life in patients with sleep-related breathing disorders

Determinants of altered quality of life in patients with sleep-related breathing disorders

Sleep Fragmentation in Children With Atopic Dermatitis

Fragmented sleep: An unrevealed problem in peritoneal dialysis patients

Contact Info

Product

Resources

About