Experimental side-wall aneurysms: a natural history study

Kallmes, David F.; Altes, T. A.; Vincent, David A.; Cloft, Harry J.; M., H.; Jensen, Mary E.

doi:10.1007/s002340050760

Cited by 26 publications

(21 citation statements)

References 3 publications

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“…Canine lateral wall aneurysms may infrequently undergo thrombosis (Ͻ10%), but most aneurysms (90%) remained patent during a follow-up period of Ն7 months. [36][37][38] Bifurcation aneurysms enlarge during the first several weeks. 38 The incidence of spontaneous thrombosis is influenced by the ratio of the volume of the aneurysm to the area of the neck (ostium).…”

Section: Angiographic Outcomesmentioning

confidence: 99%

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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SUMMARY: Animal models are necessary to develop and test innovations in aneurysm therapy before clinical introduction. This review aims at identifying the most likely candidates for standardizing preclinical testing of aneurysm devices. We systematically searched electronic databases for publications on animal aneurysm models from 1961-2008 to assess the methodologic quality of the studies and collect data on the patency and angiographic and pathologic outcomes of treatments. There has been a steady increase in the annual number of publications with time. Species that were most frequently used were dogs, rabbits, and rodents, followed by swine. Most publications are single-laboratory studies with variables and poorly validated outcome measures, a small number of subjects, and limited standardization of techniques. The most appropriate models to test for recurrences after endovascular occlusion were the surgical bifurcation model in dogs, and the elastase-induced aneurysm model in rabbits. A standardized multicenter study is needed to improve the preclinical evaluation of endovascular devices in aneurysm therapy.

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Section: Angiographic Outcomesmentioning

confidence: 99%

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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“…[1][2][3][4][5][6] However, natural history studies of experimental aneurysms are few. [7][8][9] The rate and timing of spontaneous thrombosis for different types of experimental aneurysms in different species are important to determine. Without these data, evaluations of new endovascular occlusion devices in these animal models may not be valid.…”

mentioning

confidence: 99%

Interval Change in Size of Venous Pouch Canine Bifurcation Aneurysms over a 10-Month Period

Tsumoto

Song²,

Niimi³

et al. 2008

AJNR Am J Neuroradiol

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“…This mouse model of CA would be useful for solving this problem by use of gene-altered mice. Indeed, many reports have demonstrated various experimental models of CA by a vein pouch or a vein patch, 30,31 direct injury, 32 or toxic agents, 33,34 but none of them were induced in basal cerebral arteries without direct manipulation of the intracranial arteries.…”

Section: Discussionmentioning

confidence: 99%

Mouse Model of Cerebral Aneurysm

Morimoto

Miyamoto

Mizoguchi

et al. 2002

Stroke

104

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Background and Purpose-Rupture of cerebral aneurysm (CA) is the major cause of subarachnoid hemorrhage. Molecular mechanisms of this disease, however, remain unknown. To make possible genetic analysis of CA formation with genetically altered mice, we have successfully established a mouse model of saccular CA that recapitulates the essential features of human saccular CA. Methods-In C57black/6 male mice, various stages of CAs were experimentally induced at the right anterior cerebral artery-olfactory artery bifurcations by ligations of left common carotid arteries and posterior branches of bilateral renal arteries with high salt diet. Both light and electron microscopic studies were performed with the longitudinal sections of anterior cerebral artery-olfactory artery bifurcations. Results-In the treated group, various aneurysmal changes were detected in 14 of 18 mice. On the other hand, in the control group, no aneurysmal changes were found in 15 mice. In microscopic studies, aneurysmal changes were shown to include mainly fragmentation of internal elastic lamina, thinning of the smooth muscle cell layer, and degeneration of adventitial tissue, which were very similar to critical changes in human saccular CA. Conclusions-This mouse model of CA will be useful for studying the effects of complex determinants on CA formation and makes it possible to understand the pathogenesis of CA at the molecular level. Key Words: cerebral aneurysm Ⅲ genetics Ⅲ hemodynamics Ⅲ hypertension, renal Ⅲ mice S accular cerebral aneurysm (CA) consists mainly of thinning degenerated vascular walls in contrast to aortic aneurysm, which consists of thick walls containing advanced atherosclerotic changes. 1-3 Although recent reports have shown genetic analysis on aortic aneurysms formation, 4,5 the molecular mechanisms involved in the pathogenesis of saccular CA remain unclear. The major reasons might be that human specimens are often too deformed to examine and that there have not been any suitable animal models for genetic analysis. We have previously established experimentally induced CAs in rats and monkeys, 6 -8 which were characterized by specific initial changes such as fragmentation of internal elastic lamina and thinning of the medial smooth muscle cell layer. 9,10 Their pathological features appeared very similar to those of ruptured human CA 11 ; in fact, these are the only models that have been accepted for studying the pathogenesis of human CA. However, compared with rats and monkeys, a mouse model has great advantages in genetic analysis because of a variety of established gene-modulated mice. In this report, we demonstrate the first mouse model of saccular CA that uses genetically altered mice to explore the molecular mechanisms of CA formation and provide insights into new CA prevention and treatment strategies. Methods Experimentally Treated AnimalsAs described in our previous reports, 6 -8 20 male C57black/6CrSlc mice (SLC), which were 7 to 9 weeks of age, were subjected to ligations of the left common carotid arteries and ...

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Experimental side-wall aneurysms: a natural history study

Cited by 26 publications

References 3 publications

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Interval Change in Size of Venous Pouch Canine Bifurcation Aneurysms over a 10-Month Period

Mouse Model of Cerebral Aneurysm

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