Experimental screening of two BCG preparations produced according to different principles

Kreeftenberg, J.G.; Jong, Wim H. de; Ettekoven, H.; Steerenberg, P. A.; Kruizinga, W.; Jansen, L. M. Van Noorle; Sekhuis, J.; Ruitenberg, E. J.

doi:10.1007/bf00200308

Cited by 5 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the frequent reports of toxic responses to bacterial vaccines, together with difficulties in standardizing preparations [56] is leading to a greater interest in more well defined agents including interferons [4,5] and synthetic compounds such as azimexon [42]. However, the frequent reports of toxic responses to bacterial vaccines, together with difficulties in standardizing preparations [56] is leading to a greater interest in more well defined agents including interferons [4,5] and synthetic compounds such as azimexon [42].…”

Section: Clinical Trialsmentioning

confidence: 99%

Manipulation of host resistance in cancer therapy

Baldwin

1982

Springer Semin Immunopathol

View full text Add to dashboard Cite

Section: Clinical Trialsmentioning

confidence: 99%

Manipulation of host resistance in cancer therapy

Baldwin

1982

Springer Semin Immunopathol

View full text Add to dashboard Cite

“…Immunostimulation and antitumor activity by the BCG-RIVM was observed both in experimental [14,19,21,34] and spontaneous animal tumors [17,18]. In man, this BCG preparation was studied as adjuvant immuno therapy in melanoma patients [7] and adjuvant therapy in bronchus carcinoma [12], The toxicity of the com bined intradermal and intravesical application of BCG-RIVM was investigated on normal and coagulated urothelium in the dog bladder [28].…”

Section: Introductionmentioning

confidence: 99%

Intravesical and Intradermal Bacillus Calmette-Guérin Application

Schreinemachers¹,

Meijden²,

Wagenaar³

et al. 1988

Eur Urol

View full text Add to dashboard Cite

The effects of intravesical and intradermal application of a new B.C.G. on the dog bladder

et al. 1986

Urol. Res.

View full text Add to dashboard Cite

Intravesical and intradermal application of B.C.G. (Bacillus Calmette Guérin) has proven to be effective in the prophylaxis of recurrence of superficial bladder carcinoma after transurethral resection and in the treatment of carcinoma in situ (C.I.S.) in man. Different strains of B.C.G. have been used for this purpose. In this article a new strain of B.C.G. (B.C.G.-R.I.V.M.) has been tested to assess its toxicity. The effects of intravesical and intradermal application of B.C.G.-R.I.V.M. were studied on normal and on coagulated canine urothelium. In this study no general side effects of B.C.G.-R.I.V.M. were seen. Only minor local changes occurred in the bladder wall. Small granulomas were found in the suburothelial tissue. No granulomas or signs of active inflammation were observed in the pelvic lymphnodes, spleen and liver. Because B.C.G.-R.I.V.M. seemed to be a safe agent in the dog we have started to use it for prophylaxis in superficial bladder cancer in man.

show abstract

Experimental screening of two BCG preparations produced according to different principles

Cited by 5 publications

References 22 publications

Manipulation of host resistance in cancer therapy

Manipulation of host resistance in cancer therapy

Intravesical and Intradermal Bacillus Calmette-Guérin Application

The effects of intravesical and intradermal application of a new B.C.G. on the dog bladder

Contact Info

Product

Resources

About