Experimental scoring systems for macroscopic articular cartilage repair correlate with the MOCART score assessed by a high-field MRI at 9.4 T – comparative evaluation of five macroscopic scoring systems in a large animal cartilage defect model

Goebel, Lars; Orth, Patrick; Müller, Andreas; Zurakowski, David; Bücker, Arno; Cucchiarini, Magali; Pape, Dietrich; Madry, Henning

doi:10.1016/j.joca.2012.05.010

Cited by 98 publications

(134 citation statements)

References 48 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…The histological aspect of the fibrocartilaginous repair tissue in marrow-stimulated cartilage defects is well described (Fortier et al, 2012;Frisbie et al, 1999;Furukawa et al, 1980;Goebel et al, 2012;Jackson et al, 2001;Shapiro et al, 1993). In rabbits, the access of bone marrow elements to the lesions by microfracture (Heir et al, 2012) or drill holes (Aroen et al, 2006) caused an increased filling after 9 months, when compared to defects lacking such access (Shamis et al, 1989).…”

Section: Relevance Of Subchondral Bone Alterations For Experimental Cmentioning

confidence: 99%

Alterations of the subchondral bone in osteochondral repair – translational data and clinical evidence

Orth¹,

Cucchiarini²,

Kohn³

et al. 2013

eCM

View full text Add to dashboard Cite

Alterations of the subchondral bone are pathological features associated with spontaneous osteochondral repair and with articular cartilage repair procedures. The aim of this review is to discuss their incidence, extent and relevance, focusing on recent knowledge gained from both translational models and clinical studies of articular cartilage repair. Efforts to unravel the complexity of subchondral bone alterations have identified (1) the upward migration of the subchondral bone plate, (2) the formation of intralesional osteophytes, (3) the appearance of subchondral bone cysts, and (4) the impairment of the osseous microarchitecture as potential problems. Their incidence and extent varies among the different small and large animal models of cartilage repair, operative principles, and over time. When placed in the context of recent clinical investigations, these deteriorations of the subchondral bone likely are an additional, previously underestimated factor that influences the long-term outcome of cartilage repair strategies. Understanding the role of the subchondral bone in both experimental and clinical articular cartilage repair thus holds great promise of being translated into further improved cell-or biomaterial-based techniques to preserve and restore the entire osteochondral unit. Keywords IntroductionA complete restoration of the osteochondral unit is the goal of all articular repair techniques (Brittberg et al., 1994; Johnson, 1986;Pridie, 1959;Steadman et al., 2001). Traditionally, a focus was placed on the cartilaginous repair tissue, but it is now clear that complex structural changes of the subchondral bone are associated with spontaneous osteochondral repair and with the use of cartilage repair procedures . They include (1) the upward migration of the subchondral bone plate, (2) the formation of intralesional osteophytes, (3) the appearance of subchondral bone cysts, and (4) the impairment of the osseous microarchitecture ( Fig. 1).There is accumulating experimental evidence for these subchondral bone alterations in small (Aroen et al., 2006;Chen et al., 2009;Chen et al., 2011a;Heir et al., 2012;Marchand et al., 2011;Marchand et al., 2012;Nam et al., 2004;Qiu et al., 2003) and large preclinical animal models (Dorotka et al., 2005;Frisbie et al., 1999; Hanie et al., 1992;Hoemann et al., 2005;Howard et al., 1994;Ishimaru et al., 1992;Lane et al., 2004;Orth et al., 2012b;Vachon et al., 1986) of cartilage defects. Supporting these findings, such pathological alterations were also reported in up to one third of patients treated with microfracture (Kreuz et al., 2006;Mithoefer et al., 2005; Saris et al., 2009). Moreover, autologous chondrocyte implantation (ACI) for articular cartilage defects previously treated with marrow stimulation techniques has a three-fold higher failure rate than for untreated defects Minas et al., 2009;Vasiliadis et al., 2010). In addition, upward migration of the subchondral bone plate or the development of intralesional osteophytes might also occur spontaneously in...

show abstract

Section: Relevance Of Subchondral Bone Alterations For Experimental Cmentioning

confidence: 99%

Alterations of the subchondral bone in osteochondral repair – translational data and clinical evidence

Orth¹,

Cucchiarini²,

Kohn³

et al. 2013

eCM

View full text Add to dashboard Cite

show abstract

“…Images were taken of the entire trochlear groove before sample harvest, and these gross images were later scored by four independent blinded observers using the system developed by Goebel et al 33 Samples were immediately immersed in PBS with protease inhibitors (Sigma) and frozen at -80°C until processing. At 2 and 6 weeks, samples were processed only for histology (n = 4 at 2 weeks, n = 5 at 6 weeks).…”

Section: Surgical Proceduresmentioning

confidence: 99%

Fibrous Scaffolds with Varied Fiber Chemistry and Growth Factor Delivery Promote Repair in a Porcine Cartilage Defect Model

KimIris

PfeiferChristian

FisherMatthew

et al. 2015

Tissue Engineering Part A

View full text Add to dashboard Cite

“…Geralmente, na rotina clínica e experimental veterinária, os aparelhos de RM possuem de 1,5 a 3 T, sendo este o parâmetro utilizado para a resolução espacial máxima, permitindo o exame inclusive de animais de grande porte (Goebel et al 2012). No estudo realizado por Pujol et al (2011), fez-se a avaliação anatômica da articulação do joelho em cães utilizando um equipamento de RM de 0,2 T de baixo campo, e os autores relataram que a cartilagem articular não foi claramente observada em nenhuma articulação.…”

Section: Discussionunclassified

“…Estes equipamentos fornecem uma resolução espacial me- lhor, com uma boa relação sinal-ruído dentro de um tempo relativamente curto (Goebel et al 2012). De acordo com Trattnig et al (2011), para a obtenção de uma imagem de melhor qualidade do tecido de reparação da cartilagem articular é recomendado um aparelho de alto campo, possuindo 1,5 T ou mais.…”

Section: Discussionunclassified

Ressonância magnética na avaliação de enxerto osteocondral autógeno na cartilagem articular de coelhos

et al. 2017

View full text Add to dashboard Cite

ABSTRACT. - This study aimed to determine the characteristics and applicability of magnetic resonance imaging (MRI) in the evaluation of autogenous osteochondral graft in intact or macerated format, with or without insulin-like growth factor type 1 (IGF-1) used in repair of cartilage lesions induced in rabbits. Nine New Zealand rabbits were used, in which 18 stifle joints underwent grafting procedure in the femoral trochlear groove. These were divided into four groups, referred as intact osteochondral graft + IGF-1 (n=5), intact osteochondral graft + saline solution (n=4), macerated osteochondral graft + IGF-1 (n=5) and macerated osteochondral graft + saline solution (n=4). Animals were euthanized 12 weeks after surgery and the joints were subjected to MRI using a high magnetic field scanner of 1.5 Tesla. In addition, samples of grafting sites were subjected to anatomopathological examination. The MRI was effective as a noninvasive method to evaluate the repair tissue in osteochondral grafts in articular cartilage of the femur of rabbits by providing complementary data to macroscopic and histological examinations. Through these images and anatomopathological examinations satisfactory results were observed in relation to the repair process of autogenous osteochondral grafts in cartilage of rabbits, regardless of its format or the addition of IGF-1. RESUMO.-Este trabalho teve o objetivo de determinar as características e a aplicabilidade do exame de ressonância magnética na avaliação de enxerto ostecondral autógeno, em formato íntegro ou macerado, associado ou não ao fator de crescimento semelhante à insulina tipo 1 (IGF-1), utilizado no reparo de lesões induzidas na cartilagem articular de coelhos. Foram utilizados 9 coelhos da linhagem Nova Zelândia, em que as 18 articulações fêmoro-tíbio-patelares foram submetidas à enxertia osteocondral autógena no sulco troclear femoral. Estas foram divididas em quatro grupos, denominados como enxerto osteocondral íntegro + IGF-1 (n=5), enxerto osteocondral íntegro + solução fisioló-gica (n=4), enxerto osteocondral macerado + IGF-1 (n=5) e enxerto osteocondral macerado + solução fisiológica (n=4). Os animais foram eutanasiados em 12 semanas após a cirurgia e as articulações foram submetidas ao exame de ressonância magnética utilizando um aparelho scanner de 1,5 Tesla de alto campo magnético. Além disso, amostras dos locais de enxertia foram submetidas aos exames anatomopatológicos. O exame de ressonância magnética mostrou--se eficaz como um método não invasivo para avaliação do tecido de reparação em enxertos osteocondrais na cartilagem articular do fêmur de coelhos, fornecendo dados complementares aos exames macroscópicos e histológicos. Por

show abstract

Experimental scoring systems for macroscopic articular cartilage repair correlate with the MOCART score assessed by a high-field MRI at 9.4 T – comparative evaluation of five macroscopic scoring systems in a large animal cartilage defect model

Cited by 98 publications

References 48 publications

Alterations of the subchondral bone in osteochondral repair – translational data and clinical evidence

Alterations of the subchondral bone in osteochondral repair – translational data and clinical evidence

Fibrous Scaffolds with Varied Fiber Chemistry and Growth Factor Delivery Promote Repair in a Porcine Cartilage Defect Model

Ressonância magnética na avaliação de enxerto osteocondral autógeno na cartilagem articular de coelhos

Contact Info

Product

Resources

About