Experimental Rodent Models of Cardiovascular Diseases

Jia, Tian; Wang, Chen; Han, Zhengxi; Wang, Xiaozhi; Ding, Ming; Wang, Quanyi

doi:10.3389/fcvm.2020.588075

Cited by 20 publications

(19 citation statements)

References 97 publications

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“…The increases in these mortality and morbidity rates are interpreted as a trend in developed and developing countries due to the difficulty in modifying the consolidated lifestyle habits and the several associated comorbidities that hinder the prognosis and perpetuate cardiovascular risks. From this perspective, CVDs are real burdens for health systems due to their severity, prevalence, and difficulty to treat [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

Santos

Zanuso

Miola

et al. 2021

IJMS

108

111

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Adipose, skeletal, and hepatic muscle tissues are the main endocrine organs that produce adipokines, myokines, and hepatokines. These biomarkers can be harmful or beneficial to an organism and still perform crosstalk, acting through the endocrine, paracrine, and autocrine pathways. This study aims to review the crosstalk between adipokines, myokines, and hepatokines. Far beyond understanding the actions of each biomarker alone, it is important to underline that these cytokines act together in the body, resulting in a complex network of actions in different tissues, which may have beneficial or non-beneficial effects on the genesis of various physiological disorders and their respective outcomes, such as type 2 diabetes mellitus (DM2), obesity, metabolic syndrome, and cardiovascular diseases (CVD). Overweight individuals secrete more pro-inflammatory adipokines than those of a healthy weight, leading to an impaired immune response and greater susceptibility to inflammatory and infectious diseases. Myostatin is elevated in pro-inflammatory environments, sharing space with pro-inflammatory organokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), resistin, and chemerin. Fibroblast growth factor FGF21 acts as a beta-oxidation regulator and decreases lipogenesis in the liver. The crosstalk mentioned above can interfere with homeostatic disorders and can play a role as a potential therapeutic target that can assist in the methods of diagnosing metabolic syndrome and CVD.

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Section: Introductionmentioning

confidence: 99%

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

Santos

Zanuso

Miola

et al. 2021

IJMS

108

111

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“…Mice are widely used as mammalian models with four-chamber hearts in studies to understand mechanisms underlying human heart diseases [3,4]. Mice are very tractable to genetic manipulations, and most clinically diagnosed CHDs in humans can be modeled in mutant mice [5,6].…”

Section: Introductionmentioning

confidence: 99%

Characterization of embryonic cardiac function using noninvasive volumetric optoacoustic tomography

Hatamimoslehabadi

Özbek²,

Deán‐Ben³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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The heart is the first essential organ that develops during organogenesis. Fetal impaired heart function correlates to functional cardiac anomalies and heart defects in adulthood. Therefore, noninvasive assessment of dynamic functional cardiac events during pregnancy is essential for early diagnosis of cardiac diseases. However, visualization and analysis of the small yet fast-beating embryonic heart require a high-resolution imaging platform to provide reliable volumetric analyses. Optoacoustic (OA) imaging provides excellent optical contrast along with high spatial resolution and has demonstrated an exclusive potential for noninvasive deep-tissue visualization. In this study, we used volumetric OA imaging to visualize the embryonic heart at gestational day (GD) 16.5. The anatomical structure of the embryonic heart and cardiac vasculature was visualized in three orthogonal imaging planes allowing for further quantification and structural measurements. Twenty-five volumes per second temporal resolution of OA imaging enabled assessment of embryonic cardiac dynamics. Using the temporal profile of the time-lapse OA data at different locations of the embryonic heart, the average heart rate of embryos was calculated. This study demonstrated the capability of volumetric OA tomography for noninvasive visualization of the embryonic heart and assessment of cardio dynamics at nearly video rate.

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“…Cardiovascular Disease (CVD) is a collective term for disorders of heart and blood vessels that include coronary heart disease, hypertension, and heart failure along with other heart and vascular system-related diseases such as atherosclerosis and deep venous thrombosis. CVDs are the leading cause of global mortality 1 with 17.9 million deaths each year 2 which is expected to rise to 23.6 million by 2030 3 , according to the reports of WHO four out of five CVD patients die because of heart attack or myocardial infarction every year 4 . CVD is influenced by a multitude of risk factors, prominent among these are lifestyle factors such as being overweight, having high blood sugar, increased blood pressure, smoking and unhealthy lifestyles along with genetic risk factors such as a family history of CVD that contribute to the development of CVD 5 .…”

Section: Introductionmentioning

confidence: 99%

Conserved Cardiovascular Network: Bioinformatics Insights into Genes and Pathways for EstablishingCaenorhabditis elegansas an Animal Model for Cardiovascular Diseases

Ray,

Priya,

Malik

et al. 2023

Preprint

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Cardiovascular disease (CVD) is a collective term for disorders of the heart and blood vessels. The molecular events and biochemical pathways associated with CVD are difficult to study in clinical settings on patients andin vitroconditions. Animal models play a pivotal and indispensable role in cardiovascular disease (CVD) research.Caenorhabditis elegans, a nematode species, has emerged as a prominent experimental organism widely utilised in various biomedical research fields. However, the specific number of CVD-related genes and pathways within theC. elegansgenome remains undisclosed to date, limiting its in-depth utilisation for investigations. In the present study, we conducted a comprehensive analysis of genes and pathways related to CVD within the genomes of humans andC. elegansthrough a systematic bioinformatic approach.A total of 1113 genes inC. elegansorthologous to the most significant CVD-related genes in humans were identified, and the GO terms and pathways were compared to study the pathways that are conserved between the two species. In order to infer the functions of CVD-related orthologous genes inC. elegans, aPPI network was constructed. Orthologous gene PPI network analysis results reveal the hubs and important KRs:pmk-1, daf-21, gpb-1, crh-1, enpl-1, eef-1G, acdh-8, hif-1, pmk-2,andaha-1 in C. elegans.Modules were identified for determining the role of the orthologous genes at various levels in the created network. We also identified 9 commonly enriched pathways between humans andC. eleganslinked with CVDs that include autophagy (animal), the ErbB signalling pathway, the FoxO signalling pathway, the MAPK signalling pathway, ABC transporters, the biosynthesis of unsaturated fatty acids, fatty acid metabolism, glutathione metabolism, and metabolic pathways. This study provides the first systematic genomic approach to explore the CVD-associated genes and pathways that are present inC. elegans,supporting the use ofC. elegansas a prominent animal model organism for cardiovascular diseases.

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Experimental Rodent Models of Cardiovascular Diseases

Cited by 20 publications

References 97 publications

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

Characterization of embryonic cardiac function using noninvasive volumetric optoacoustic tomography

Conserved Cardiovascular Network: Bioinformatics Insights into Genes and Pathways for EstablishingCaenorhabditis elegansas an Animal Model for Cardiovascular Diseases

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