Experimental rhinovirus challenges in adults with mild asthma: Response to infection in relation to IgE

Zambrano, Juan C.; Carper, Holliday T.; Rakes, Gary P.; Patrie, James T.; Murphy, Deborah D.; Platts-Mills, Thomas A.E.; Hayden, Frederick G.; Gwaltney, Jack M.; Hatley, Tina; Owens, Angela; Heymann, Peter W.

doi:10.1067/mai.2003.1396

Cited by 120 publications

(116 citation statements)

References 30 publications

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“…The interaction between atopy and viral infections is complex [18]. The atopic state influences lower airway responses to viral infections and viral infections can influence the development of allergic sensitisation, especially when individuals are exposed simultaneously to both.…”

Section: Panel Consensus Judgmentmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2008

European Respiratory Journal

2,638

2,301

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Asthma is a serious health problem throughout the world. During the past two decades, many scientific advances have improved our understanding of asthma and ability to manage and control it effectively. However, recommendations for asthma care need to be adapted to local conditions, resources and services. Since it was formed in 1993, the Global Initiative for Asthma, a network of individuals, organisations and public health officials, has played a leading role in disseminating information about the care of patients with asthma based on a process of continuous review of published scientific investigations. A comprehensive workshop report entitled ''A Global Strategy for Asthma Management and Prevention'', first published in 1995, has been widely adopted, translated and reproduced, and forms the basis for many national guidelines. The 2006 report contains important new themes. First, it asserts that ''it is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained,'' and recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions. The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised.

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Section: Panel Consensus Judgmentmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2008

European Respiratory Journal

2,638

2,301

View full text Add to dashboard Cite

show abstract

“…There are many triggers that lead to an increase in symptoms or exacerbations including respiratory infections, allergens, irritants, and occupational exposures among others. Although it is thought that allergen sensitisation acts in synergy with other pro-inflammatory environmental cofactors, such as respiratory viral infections [9], the current study indicates that this may also apply to nonatopic asthma. The annual exacerbation rate in patients treated with placebo plus standard of care was similar in the atopic and nonatopic patients, 2.41 and 2.33 exacerbations per year, respectively.…”

mentioning

confidence: 90%

The role of mepolizumab in atopic and nonatopic severe asthma with persistent eosinophilia

Ortega

Chupp

Bardin

et al. 2014

European Respiratory Journal

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“…Segmental allergen challenge of the lung and experimental RV infection have illustrated that concurrent exposure to allergen and virus increase the risk of asthma exacerbation (Calhoun et al, 1994;Lemanske et al, 1989). Exposure to RV results in persistent upper and significantly increased lower respiratory symptoms in young asthmatic adults with atopic characteristics in contrast to non-atopic ones (Zambrano et al, 2003). Experimental inoculation with RV is more likely to increase airway responsiveness, in allergic than in non-allergic individuals (Gern et al, 1997).…”

Section: Interactions Of Viral Infection With Atopic Host Immune Respmentioning

confidence: 98%