Experimental Research on Therapeutic Efficacy of Traditional Chinese Medicine Shengjing Capsule Extracts in Treating Spermatogenesis Impairment Induced by Oxidative Stress

Zhou, Shaohu; Zhang, Wen; Liang, Aijun; Zhang, Shuting

doi:10.12659/msm.895336

Cited by 23 publications

(20 citation statements)

References 4 publications

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“…The GPx and GST are key enzymes that take part in maintaining glutathione homeostasis in the tissues. GPx and GST as antioxidant enzymes work together with GSH in the decomposition of H 2 O 2 and other organic hydroperoxides (Zhou et al, ). We therefore proposed that the participation of this array of antioxidant enzymes constituted a major part of defense system against free radical mediated tissue or cellular damage after NaF exposure.…”

Section: Discussionmentioning

confidence: 99%

Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

Oyagbemi

Omobowale

Asenuga

et al. 2016

Environmental Toxicology

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Human exposure to sodium fluoride through its daily usage is almost inevitable. Cardiovascular and renal dysfunction has been associated with fluoride toxicity. Therefore, this study investigated the mechanism of action of sodium fluoride (NaF) induced hypertension and cardiovascular complications Forty male albino rats of an average of 10 rats per group were used. Group A received clean tap water. Toxicity was induced in Group B to D by administering graded doses of NaF through drinking water ad libitum for 10 days at 150 ppm, 300 ppm, and 600 ppm concentration respectively. Following administration of NaF, there was significant increase in systolic pressure, diastolic pressure and mean arterial pressure. Markers of oxidative stress; malondialdehyde, hydrogen peroxide, advance oxidation protein products, and protein carbonyl were significantly increased in dose-dependent pattern in the cardiac and renal tissues of rats together with significant decrease in the GST activity in NaF-treated rats compared to the control. Also serum markers of inflammation, cardiac, and renal damage including myeloperoxidase, xanthine oxidase, blood urea nitrogen, creatinine, Lactate dehydrogenase (LDH), and Creatinine kinase myocardial band (CK-MB) significantly increased indicating induction of oxidative stress, renal, and cardiac damage after exposure. Histopathology of the kidney and heart revealed aberrations in the histological architecture in NaF-treated rats. Also, immunohistochemistry showed higher expression of nuclear factor kappa beta (NF-kB) in the cardiac and renal tissues of rats administered NaF. Combining all, these results indicate NaF-induced hypertension through generation of reactive oxygen species and activation of renal and cardiac NF-kB expressions. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1089-1101, 2017.

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Section: Discussionmentioning

confidence: 99%

Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

Oyagbemi

Omobowale

Asenuga

et al. 2016

Environmental Toxicology

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“…with saline (vehicle of CdCl 2 ) and served as the control group, Group II (G II) received a single dose of 1 mg/kg BW of CdCl 2 (Cd, dissolved in saline solution, i.p.) according to the previous studies (Chen, Zhou, Gao, & Jiang, ; Zhou, Wen, Liang, & Zhang, ), Group III (G III) that received royal jelly (RJ) orally at dose of 100 mg/kg daily, Group IV (G IV) was pre‐treated with RJ for 1 week then received single injection of Cd as in G II and Group V (G V) received a single dose of Cd as in G II simultaneously with RJ treatment (i.e., co‐treated with both RJ and single of Cd). The choice of dose and regimen of treatment with oral royal jelly was performed according to the previous studies (Amirshahi, Najafi, & Nejati, ; Silici, Ekmekcioglu, Kanbur, & Deniz, ).…”

Section: Methodsmentioning

confidence: 99%

Protective potential of royal jelly against cadmium‐induced infertility in male rats

et al. 2018

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This study aimed to investigate the protective potential of Royal jelly (RJ) against cadmium (Cd)-induced testicular dysfunction in rats. Thirty-five adult male Wistar rats were assigned into five groups. G I; (control) injected intraperitoneally with saline, G II injected intraperitoneally with a single dose of CdCl (1 mg/kg BW), G III received RJ (100 mg/kg BW/day) orally, G IV was pre-treated with RJ for 1 week then, treated with CdCl , and G V was co-treated with RJ and CdCl . After day 56, serum and tissue samples were collected and analysed. The results showed decreased serum testosterone, luteinising hormone (LH), follicle-stimulating hormone (FSH), superoxide dismutase, glutathione reductase, sperm motility and count while increased malondialdehyde, nitric oxide, tumour necrosis factor-α (TNF-α) and sperm abnormalities, along with a severely damaged seminiferous tubules epithelium with cytoplasmic and nuclear disruptions following Cd toxicity. Additionally, Cd stimulated testicular mRNA expression of TNF-α while inhibited those of steroidogenic acute regulatory protein, cytochrome P450 cholesterol side chain cleavage enzyme androgen binding protein, FSH-receptor, LH-receptor, androgen receptor, 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, and cytochrome P450 17A1. These negative alterations of cadmium were greatly reduced by RJ treatment. This study concluded that RJ protects against Cd-induced testicular toxicity.

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“…59 Modern research suggests that vitality. 35,60 Recent studies found the therapeutic function of velvet antler polypeptide 61 and total flavonoids of Epimedium 62 for…”

Section: Discussionmentioning

confidence: 99%

“…reproductive system, which may be responsible for the clinical efficacy of Shenjing capsule for male infertility. In addition, growing evidence has revealed that TCM can not only regulate the reproductive endocrine system, 63 but it can also regulate luteinizing hormone levels, 64 raise testosterone levels, 65 boost the function of Sertoli cells and Leydig cells, 66 prevent oxidative stress, 67,68 modulate the proliferation and apoptosis of germ cells, 67,68 and supplement trace elements. 69 With the continuous exploration of integrated TCM and Western medicine therapy, its advantages in male infertility treatment will be further highlighted.…”

Section: Discussionmentioning

confidence: 99%

Vitamins combined with traditional Chinese medicine for male infertility: A systematic review and meta‐analysis

Wang

et al. 2020

Andrology

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Background Male infertility is a tough problem in medicine. This article aims to provide the latest evidence for the efficacy and safety of traditional Chinese medicine (TCM) combined with vitamins in the treatment of male infertility. Method All randomized controlled trials (RCTs) that used TCM combined with vitamins for male infertility treatment were included in databases of China National Knowledge Infrastructure (CNKI), Wanfang, VIP Database, China Biology Medicine disc (CBM), MEDLINE, EMBASE, and Cochrane Library. The quality of the included articles was evaluated using the Cochrane Reviewer's Handbook 5.3, and meta‐analysis was performed using Stata 15. Results A total of 14 eligible studies with 1488 patients were included in this meta‐analysis. The results suggested that, compared with vitamin E or vitamin E + C alone, combination of TCM with vitamins increased significantly sperm concentration, sperm motility, sperm viability, liquefaction time of semen, the activity of acrosome enzyme, and the pregnancy rate of patients with male infertility. Three kinds of TCM (Shengjing capsule, Huanshao capsule, and compound Xuanju capsule) showed significant improvement for male infertility in terms of pregnancy rate, sperm concentration, or sperm motility. In addition, the results of the publication bias test demonstrated that no significant bias occurred. Conclusion Traditional Chinese medicine combined with vitamins has significant efficacy in the treatment of male infertility with no increase in side effects. The specific implementing regulations still need more long‐term, multicenter, randomized, and double‐blind clinical trials.

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Experimental Research on Therapeutic Efficacy of Traditional Chinese Medicine Shengjing Capsule Extracts in Treating Spermatogenesis Impairment Induced by Oxidative Stress

Cited by 23 publications

References 4 publications

Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

Protective potential of royal jelly against cadmium‐induced infertility in male rats

Vitamins combined with traditional Chinese medicine for male infertility: A systematic review and meta‐analysis

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