Based on the analysis of comparability, a bench‐scale (1 : 4) facility with the configuration of a “fire room‐long passage‐remote room” has been designed to study the spatial distribution and risk of toxic gases in building fires. Experiments conducted with the facility showed that concentrations of toxic gases (CO) increased with probe height in the non‐firesource‐field. In the long term, the CO concentration decreased with distance from the fire source. CO concentrations were shown to vary widely at the upper long passage, but to be uniform at the lower long passage. The CO distribution in the remote room was in direct contrast, with CO concentrations greatly influenced by the openings. The characteristics of CO distribution in a non‐firesource‐field indicated that the long passage and remote room should be treated differently from a research aspect. The characteristics of smoke movement were investigated by numerical simulation, and the results of simulations and experiments compared to provide a clear understanding. In this chapter, the concept of an index of toxicity is proposed for analyzing smoke toxicity in a non‐firesource‐field, and to assess the risk grade in this environment.