Experimental research in topical psoriasis therapy (Review)

Abstract

Psoriasis, one of the most prevalent inflammatory diseases in dermatologic pathology, remains a challenge in regards to the therapeutic approach. Topical therapy for psoriasis is a current trending subject as it implies good compliance for the patient, few adverse systemic reactions and a targeted effect. Numerous substances are now being tested, from natural to synthetic compounds and already known substances in improved formulas such as vesicular systems. The aim of this article was to conduct a literature review regarding the topical therapy of psoriasis in animal models, between June, 27, 2019 and July 9, 2020. For this article, the authors conducted extensive research in PubMed with the following keywords: Psoriasis AND (topical OR local) and (therapy OR treatment) AND (mice OR rats). The main new studied substances included lycopene, sodium butyrate, salvianolic acid B, small interfering RNAs (siRNAs) in ionic liquids, albendazole, phosphodiesterase inhibitors, biomimetic reconstituted highdensity lipoprotein nanocarrier gel containing microRNA (miRNA)-210 antisense, thymoquinone in ethosomal vesicle, Sea buckthorn oil (Hippophae rhamnoides), nitidine chloride, Melissa officinalis spp. Altissima extract and [1-(4-chloro-3nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (CIM). New formulas of already known anti-psoriasis substances such as: Cyclosporine, methotrexate, calcipotriol, tazarotene, protein kinase p38 and integrin α5β1 as a target, are also reviewed. Recent research in topical psoriasis underlines the importance of animal experimental research in dermatology, providing a starting point for developing new therapeutic approaches in one of the most frequently diagnosed chronic dermatologic diseases. Vesicular systems are now providing the best vehicle for topical therapy, thus easing the action of the active substances at their target sites. Contents 1. Introduction 2. Research methods 3. Summary and discussion of the new topical treatment strategies 4. Discussion 5. Conclusions

Alternations in the human skin, gut and vaginal microbiomes in perimenopausal or postmenopausal Vulvar lichen sclerosus

“…Furthermore, butyrate decreases intestinal barrier permeability and improves epithelial barrier integrity. Sodium butyrate has been utilized to treat psoriasis and other hyperproliferative skin diseases by regulating several crucial cellular processes such as differentiation, proliferation and apoptosis 56 .…”

Design and Evaluation of Tretinoin Fatty Acid Vesicles for the Topical Treatment of Psoriasis

“…It is believed that most of the triggers of skin disease are to be found under the skin, and locally delivered medication is favoured over more systemic approaches. At current levels, topical therapy is the cornerstone of treatment for mild to moderate-to-severe psoriasis and is often the first-line and complementary treatment for more severe psoriasis [10,11]. Traditional treatment usually involves applying anti-psoriasis medication in the form of ointments, creams or lotions directly to the diseased skin tissue, with the frequency of application varying depending on the severity of the inflammation, averaging 1-2 times per day.…”