Experimental reproduction of respiratory tract disease with bovine respiratory syncytial virus

Ciszewski, D.K.; Baker, John C.; Slocombe, R. F.; Reindel, J. F.; Haines, Deborah M.; Clark, Edward G.

doi:10.1016/0378-1135(91)90098-z

Cited by 28 publications

(30 citation statements)

References 18 publications

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“…In these studies and in contrast to ours the virus isolate was ap-plied intranasally and/or intratracheally. This route of infection does not represent the natural pathway of infection and explains the discrepancy between the localization of the development of bronchiolitis in our studies and in those of Ciszewski et al [6].…”

Section: Discussioncontrasting

confidence: 99%

Respiratory syncytial virus-induced chronic bronchiolitis in experimentally infected calves

et al. 2000

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Human (RSV) and bovine (BRSV) respiratory syncytial virus cause similar infections of the lower respiratory tract. Therefore, experimentally infected calves are suited to the study of RSV-induced chronic bronchiolitis. Colostrum-fed calves aged 17-24 days were successfully infected with BRSV. BRSV strain 375 was applied as an aerosol on 4 consecutive days. Clinical symptoms were already evident on the 1st day after infection. The calves were necropsied 12 weeks after the first infection. Focal severe chronic bronchiolitis with atelectasis and focal bronchiolitis obliterans were demonstrated. The bronchiolar lumina were filled with secretion. Transmission electron microscopy revealed an alteration of the ciliogenesis and partial loss of cilia. Immunhistochemically virus P protein could still be detected, mainly in the epithelial cells of the inflamed bronchioli.

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Section: Discussioncontrasting

confidence: 99%

Respiratory syncytial virus-induced chronic bronchiolitis in experimentally infected calves

et al. 2000

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“…Experimental bRSV infection resulting in severe respiratory disease in cattle has been described in only a few reports (3,5,6). However, a potential drawback of these studies is that it was unclear in these studies whether other pathogenic microorganisms might also have been involved in pathogenesis.…”

mentioning

confidence: 99%

“…However, a potential drawback of these studies is that it was unclear in these studies whether other pathogenic microorganisms might also have been involved in pathogenesis. For instance, severe respiratory disease after bRSV infection was reported by Ciszewski et al (6), but the calves used were not specific pathogen free (SPF) and pathogenic microorganisms were in fact cultured from several animals in the experiment. Evidently, for further study of the (immuno)pathogenesis of bRSV infection and for evaluation of vaccine safety and efficacy, development of a bRSV infection model is urgently needed.…”

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confidence: 99%

Vaccine-Induced Immunopathology during Bovine Respiratory Syncytial Virus Infection: Exploring the Parameters of Pathogenesis

Antonis¹,

Schrijver²,

Daus³

et al. 2003

J Virol

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The bovine and human respiratory syncytial viruses cause severe lower respiratory tract infections. Effective vaccines against the respiratory syncytial viruses have been lacking since vaccine failures in the 1960s and 1970s. In this report, we describe a bovine respiratory syncytial virus (bRSV) challenge model in which both classical bRSV respiratory infection and vaccine-enhanced immune pathology were reproduced. The classical, formalin-inactivated (FI) bRSV vaccine that has been associated with vaccine failure was efficient in inducing high antibody titers and reducing viral loads but also primed calves for a far more serious enhanced respiratory disease after a bRSV challenge, thereby mimicking the enhanced clinical situation in FI human RSV (hRSV)-immunized and hRSV-infected infants in the 1960s. We show that immunization with FI-bRSV mainly primes a Th2-like inflammatory response that is characterized by a significant eosinophilic influx in the bronchial alveolar lung fluid and lung tissues and high levels of immunoglobulin E serum antibodies. The current model may be useful in the evaluation of new bRSV candidate vaccines for potency and safety.

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“…Observations on the naturally occurring respiratory tract disease associated with BRSV and the results from experimental infections indicate that passively derived antibody does not prevent infections (6, 9, 10, 23,60,65,80,83). There has been no evidence presented that maternally-derived antibody enhances the severity of disease associated with BRSV infections in calves.…”

Section: Serum Antibody Interacting With Virus (Type 3 Hypersensitivimentioning

confidence: 99%

“…As suggested for HRSV infections, genetic factors may also be important in controlling the immune response following infection. In a recent study, calves were initially infected with BRSV and rechallenged 10 days later using the same infection protocol (24). Rechallenge did not cause a more severe disease.…”

Section: Prior Sensitising Infection (Type I Hypersensitivity)mentioning

confidence: 99%

Human and bovine respiratory syncytial virus: Immunopathologic mechanisms

Baker

1991

Veterinary Quarterly

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Experimental reproduction of respiratory tract disease with bovine respiratory syncytial virus

Cited by 28 publications

References 18 publications

Respiratory syncytial virus-induced chronic bronchiolitis in experimentally infected calves

Respiratory syncytial virus-induced chronic bronchiolitis in experimentally infected calves

Vaccine-Induced Immunopathology during Bovine Respiratory Syncytial Virus Infection: Exploring the Parameters of Pathogenesis

Human and bovine respiratory syncytial virus: Immunopathologic mechanisms

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