Experimental reproduction of bluetongue virus serotype 8 clinical disease in calves

Pozzo, Fabiana Dal; Clercq, Kris De; Guyot, Hugues; Vandemeulebroucke, E.; Sarradin, Pierre; Vandenbussche, Frank; Thiry, Étienne; Saegerman, Claude

doi:10.1016/j.vetmic.2008.11.012

Cited by 33 publications

(25 citation statements)

References 17 publications

(24 reference statements)

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“…Like in other similar works (Dal Pozzo et al, 2009), the use of a scoring approach allowed us to appreciate the effects of infection in each individual, describe precisely the progression of the disease over time, and compare its consequences between the mares. The total clinical score of mare G (first experiment) was highly similar to that of mare A (second experiment).…”

Section: Discussionmentioning

confidence: 99%

Experimental infection with equid herpesvirus 3 in seronegative and seropositive mares

Barrandeguy¹,

Vissani²,

Olguin³

et al. 2012

Veterinary Microbiology

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Section: Discussionmentioning

confidence: 99%

Experimental infection with equid herpesvirus 3 in seronegative and seropositive mares

Barrandeguy¹,

Vissani²,

Olguin³

et al. 2012

Veterinary Microbiology

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“…According to recent experimental infection in cattle with BTV-8 [32], the kinetics of the Cq values and clinical score were determined. Cq values decreased progressively after infection and had a value of about 28 at 7–15 days post infection (dpi).…”

Section: Discussionmentioning

confidence: 99%

The Most Likely Time and Place of Introduction of BTV8 into Belgian Ruminants

et al. 2010

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BackgroundIn northern Europe, bluetongue (BT) caused by the BT virus (BTV), serotype 8, was first notified in August 2006 and numerous ruminant herds were affected in 2007 and 2008. However, the origin and the time and place of the original introduction have not yet been determined.Methods and Principal FindingsFour retrospective epidemiological surveys have been performed to enable determination of the initial spatiotemporal occurrence of this emerging disease in southern Belgium: investigations of the first recorded outbreaks near to the disease epicenter; a large anonymous, random postal survey of cattle herds and sheep flocks; a random historical milk tank survey of samples tested with an indirect ELISA and a follow-up survey of non-specific health indicators. The original introduction of BTV into the region probably occurred during spring 2006 near to the National Park of Hautes Fagnes and Eifel when Culicoides become active.Conclusions/SignificanceThe determination of the most likely time and place of introduction of BTV8 into a country is of paramount importance to enhance awareness and understanding and, to improve modeling of vector-borne emerging infectious diseases.

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“…It could result from a secondary effect of fever in infected cows triggering calving. Fever is the most frequent clinical sign of BTV and it occurs 1 d after the infection Dal Pozzo et al, 2009). However, no study showing this secondary effect has been found.…”

Section: The Magnitude Of Btv Effects On Reproductive Performance Indmentioning

confidence: 99%

Can routinely recorded reproductive events be used as indicators of disease emergence in dairy cattle? An evaluation of 5 indicators during the emergence of bluetongue virus in France in 2007 and 2008

Marceau

Madouasse

Lehébel

et al. 2014

Journal of Dairy Science

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In response to increasing risks of emerging infectious diseases, syndromic surveillance can be a suitable approach to detect outbreaks of such diseases across a large territory in an early phase. To implement a syndromic surveillance system, the primary challenge is to find appropriate health-related data. The objective of this study was to evaluate whether routinely collected dates of reproductive events in dairy cattle could be used to build indicators of health anomalies for syndromic surveillance. The evaluation was performed on data collected in France between 2003 and 2009. First, a set of 5 indicators was proposed to assess several types of reproductive disorders. For each indicator, the demographic coverage over the total number of cattle at risk was analyzed in time and space. Second, the ability to detect an emerging disease in an early phase was retrospectively evaluated during epidemics of bluetongue serotypes 1 and 8 (BTV-1, BTV-8) in France in 2007 and 2008. Reproductive indicators were analyzed weekly during these epidemics for each indicator in each infected French district (16 in 2007 and 50 in 2008 out of 94 districts). The indicators were able to detect the BTV epidemics despite their low demographic coverage on a weekly basis relatively to total number of cattle (median=1.21%; range=0-11.7%). Four indicators related to abortions, late embryonic death, and short gestations were abnormally elevated during both BTV epidemics. Median times to abnormal elevations in these indicators were 20 to 71 d after the first notification of clinical signs of BTV by veterinarians. These results demonstrate that reproduction data can be used as indicators of disease emergences, whereas in the specific case of these BTV epidemics, detection via these indicators was later than clinical detection by veterinarians. The emergence of bluetongue in 2007 in France was associated with gestations that were a few days shorter than expected. A short gestation indicator underwent high elevations relative to prior random fluctuations and was the earliest (out of the 4 indicators) to show abnormal elevations, making it possible to detect this emergence.

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Experimental reproduction of bluetongue virus serotype 8 clinical disease in calves

Abstract: International audienc

Cited by 33 publications

References 17 publications

Experimental infection with equid herpesvirus 3 in seronegative and seropositive mares

Experimental infection with equid herpesvirus 3 in seronegative and seropositive mares

The Most Likely Time and Place of Introduction of BTV8 into Belgian Ruminants

Can routinely recorded reproductive events be used as indicators of disease emergence in dairy cattle? An evaluation of 5 indicators during the emergence of bluetongue virus in France in 2007 and 2008

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