Experimental repair of venous valvular insufficiency using a cryopreserved venous valve allograft aided by a distal arteriovenous fistula

Burkhart, Harold M.; Fath, Steven W.; Dalsing, Michael C.; Sawchuk, Alan P.; Cikrit, Dolores F.; Lalka, Stephen G.

doi:10.1016/s0741-5214(97)70095-8

Cited by 20 publications

(12 citation statements)

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“…Supported by a dAVF for 3-6 weeks, the transplants have remained patent and competent for ∼3 weeks following dAVF ligation. 29 Lower limb venous hemodynamics were improved similar to that observed after implantation of an Eiseman/ Malette type valve. No long-term studies are available for this valve.…”

Section: Venous Valve Substitutessupporting

confidence: 68%

Animal Models for the Study of Lower Extremity Chronic Venous Disease: Lessons Learned and Future Needs

Dalsing

Ricotta

Wakefield

et al. 1998

Annals of Vascular Surgery

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The purpose of this review is to define animal models of chronic venous disease and to demonstrate how animal studies can impact our understanding and treatment of this disorder. To this end an extensive literature search was conducted highlighting potential animal models of chronic lower extremity venous disease. Scientific investigations using animals to study particular aspects of this disease are also reviewed. This review was conducted by members of the Committee on Research of the American Venous Forum to help provide direction for future venous research endeavors. Useful models of chronic venous occlusive disease involve controlled ligation of a major lower limb vein and multiple tributaries. Such a model can provide sustained venous hypertension and studies using this model have confirmed that an isodiametric graft can provide early hemodynamic relief. Models of primary, postphlebitic, and isolated chronic deep venous insufficiency are available for study. Valve repair or transplantation can positively impact the insufficiency observed in these models. Investigations into valve substitutes have generally been disappointing or are undergoing early evaluation. In conclusion, animal models for the study of some aspects of chronic venous disease do exist and have already affected our clinical approach to patients. The scientific study of basic pathophysiology, diagnostics, end-organ response, and long-term surgical treatments of this disorder in well-controlled animal experiments have not been conducted.

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Section: Venous Valve Substitutessupporting

confidence: 68%

Animal Models for the Study of Lower Extremity Chronic Venous Disease: Lessons Learned and Future Needs

Dalsing

Ricotta

Wakefield

et al. 1998

Annals of Vascular Surgery

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“…Valve replacement therapy is currently being explored for central veins and might become available in the future ( Weber et al, 2016 ). VV allografts (the transplantation of valves from living donors or cadavers) are showing promising results in clinical and pre-clinical trials ( Burkhart et al, 1997 ; Dalsing et al, 1999 ).…”

Section: Mammalian Valves: An Overviewmentioning

confidence: 99%

Intraluminal valves: development, function and disease

Geng

Cha

Mahamud

et al. 2017

Disease Models &Amp; Mechanisms

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The circulatory system consists of the heart, blood vessels and lymphatic vessels, which function in parallel to provide nutrients and remove waste from the body. Vascular function depends on valves, which regulate unidirectional fluid flow against gravitational and pressure gradients. Severe valve disorders can cause mortality and some are associated with severe morbidity. Although cardiac valve defects can be treated by valve replacement surgery, no treatment is currently available for valve disorders of the veins and lymphatics. Thus, a better understanding of valves, their development and the progression of valve disease is warranted. In the past decade, molecules that are important for vascular function in humans have been identified, with mouse studies also providing new insights into valve formation and function. Intriguing similarities have recently emerged between the different types of valves concerning their molecular identity, architecture and development. Shear stress generated by fluid flow has also been shown to regulate endothelial cell identity in valves. Here, we review our current understanding of valve development with an emphasis on its mechanobiology and significance to human health, and highlight unanswered questions and translational opportunities.

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“…Alternative valve materials, such as cryopreserved venous allografts, xenografts, and platinum valves, have been advocated in an attempt to overcome the supply limitations of autogenous valve, but these have thus far not been successful due to overwhelmingly low patency and competence rates. [23][24][25] In these studies, the behavior of the transplanted valves was disappointing due to absorption and disintegration of the valve leaflets (preserved allografts and xenografts) or thrombosis (platinum valves), possibly owing to storage technique and allograft rejection. 26 Glutaraldehyde-fixed grafts appear to func-tion well for prolonged periods of time in both high and low-pressure environments.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, even a low-grade process could affect early competence without obvious histological changes. 25 Therefore, issues such as bioprosthesis durability, immunogenicity, and leaflet function will need to be evaluated with long-term studies.…”

Section: Discussionmentioning

confidence: 99%

A Percutaneous Approach to Deep Venous Valve Insufficiency with a New Self-Expanding Venous Frame Valve

Borst

Teijink

Patterson³

et al. 2003

J Endovasc Ther

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Experimental repair of venous valvular insufficiency using a cryopreserved venous valve allograft aided by a distal arteriovenous fistula

Abstract: A cryopreserved venous valve allograft transplanted to the SFV of an incompetent hindlimb partially corrects venous hemodynamics. A high-flow arteriovenous fistula most consistently preserves transplant patency.

Cited by 20 publications

References 10 publications

Animal Models for the Study of Lower Extremity Chronic Venous Disease: Lessons Learned and Future Needs

Animal Models for the Study of Lower Extremity Chronic Venous Disease: Lessons Learned and Future Needs

Intraluminal valves: development, function and disease

A Percutaneous Approach to Deep Venous Valve Insufficiency with a New Self-Expanding Venous Frame Valve

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